3 documents found, page 1 of 1
Evolutionary history and functional characterization of duplicated G protein-co...
Zapater, Cinta; Moreira, Catarina; Knigge, Thomas; Monsinjon, Tiphaine; Gómez, Ana; Pinto, Patricia I. S.Across vertebrates, the numerous estrogenic functions are mainly mediated by nuclear and membrane receptors, including the G protein-coupled estrogen receptor (GPER) that has been mostly associated with rapid non-genomic responses. Although Gper-mediated signalling has been characterized in only few fish species, Gpers in fish appear to present more mechanistic functionalities as those of mammals due to additio...
Differential involvement of the three nuclear estrogen receptors during oogenes...
Zapater, Cinta; Molés, Gregorio; Muñoz, Iciar; Pinto, Patricia IS; Canario, Adelino; Gómez, AnaEstrogens are involved in a wide range of processes in vertebrate reproduction through ligand activation of their specific cognate receptors. In most teleosts, three nuclear estrogen receptor subtypes have been identified (Esr1, Esr2a, and Esr2b). Differences in ligand binding affinity and seasonal expression patterns in reproductive tissues among these Esr subtypes suggest distinct roles during oogenesis, vite...
Genistein and estradiol have common and specific impacts on the sea bass (Dicen...
Pinto, Patricia IS; Andrade, André; Moreira, Catarina; Zapater, Cinta; Thorne, Michael A.S.; Santos, Soraia; Estêvão, M. Dulce; Gomez, AnaTeleost fish scales play important roles in animal protection and homeostasis. They can be targeted by endogenous estrogens and by environmental estrogenic endocrine disruptors. The phytoestrogen genistein is ubiquitous in the environment and in aquaculture feeds and is a disruptor of estrogenic processes in vertebrates. To test genistein disrupting actions in teleost fish we used a minimally invasive approach ...