9 documents found, page 1 of 1

Introducing the OECD guidance document on occupational biomonitoring

Publisher Copyright: © 2024 The Authors; Derivation of occupational biomonitoring levels (OBLs) is needed to effectively utilize biomonitoring for assessing exposures to chemical substances, and consequently, implement risk reduction measures to reduce health risks among workers. OBLs are the appropriate option for chemical substances that can be absorbed through the skin. This methodology for derivation of OBL...

Guidance on minimum information requirements (MIR) from designing to reporting ...

Funding Information: We would like to thank all the experts active in the International Society for Exposure Science (ISES) European Regional Chapter, working group on Human biomonitoring (ISES Europe HBM working group) and the HBM Global Network for their support and contributions. Additionally, special thanks to ECETOC for supporting this initiative and development of www.FAIREHR.com platform. Ethical approva...

Human biomonitoring and toxicokinetics as key building blocks for next generati...

Publisher Copyright: © 2024 The Author(s); Human health risk assessment is historically built upon animal testing, often following Organisation for Economic Co-operation and Development (OECD) test guidelines and exposure assessments. Using combinations of human relevant in vitro models, chemical analysis and computational (in silico) approaches bring advantages compared to animal studies. These include a great...

A harmonized occupational biomonitoring approach

Publisher Copyright: © 2024; Biomonitoring has been widely used in assessing exposures in both occupational and public health complementing chemical risk assessments because it measures the concentrations of chemical substances in human body fluids (e.g., urine and blood). Biomonitoring considers all routes and sources of exposure. An occupational biomonitoring guidance document has been elaborated (OECD Occupa...

FAIR environmental and health registry (FAIREHR)

Funding Information: Most co-authors were financialy supported with their respective inistitution. Some of the co-authors were financialy supportrd by the “Safe and Efficient Chemistry by Design (SafeChem)” project (grant no. DIA 2018/11) funded by the Swedish Foundation for Strategic Environmental Research, and by the PARC project (grant no. 101057014) funded under the European Union’s Horizon Europe Research ...

Towards further harmonization of a glossary for exposure science

Developing human biomonitoring as a 21st century toolbox within the European ex...

Funding Information: The authors are grateful to all experts from academia, institutes and industry that have participated in discussions that helped formulate the present strategy paper. They would also like to thank ISES Europe for initiating the discussions to prepare a European Exposure Science Strategy 2030. The German Federal Institute for Occupational Safety and Health (BauA), National Institute for Publ...

A human biomonitoring (HBM) Global Registry Framework

Funding Information: Stephanie Bopp (European Commission, DG Joint Research Centre) is acknowledged to provide valuable information regarding the IPCHEM Platform. The VITO HBM data management team is acknowledged for providing specific input. The HBM expert working group of the European Chapter of the International Society for Exposure Science (ISES Europe) is acknowledged for their great support. Publisher Cop...

Towards a systematic use of effect biomarkers in population and occupational bi...

Effect biomarkers can be used to elucidate relationships between exposure to environmental chemicals and their mixtures with associated health outcomes, but they are often underused, as underlying biological mechanisms are not understood. We aim to provide an overview of available effect biomarkers for monitoring chemical exposures in the general and occupational populations, and highlight their potential in mo...