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Self-glucose feeding hydrogels by enzyme empowered degradation for 3D cell culture

Zargarzadeh, Mehrzad; Silva, A. Sofia; Nunes, Cláudia; Coimbra, Manuel A.; Custódio, Catarina A.; Mano, João F.

Hydrogels have been used in combination with cells for several biomedical and biotechnological applications. Nevertheless, the use of bulk hydrogels has exhibited severe limitations in diffusion of oxygen, nutrients, and metabolites. Here, a support for cell culture is reported where glucose is generated in situ by the own hydrogel degradation, allowing cell survival and function while promoting tissue growth. ...

Date: 2022   |   Origin: RIA - Repositório Institucional da Universidade de Aveiro
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