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Antimetastatic effect of the pharmacological inhibition of serine/arginine-rich...
Moreira, Gabriela Alves; Lima, Graziela Domingues de Almeida; Siqueira, Raoni Pais; Barros, Marcus Vinícius de AndradeThe Serine/arginine-rich protein kinases (SRPK) are involved in pre-mRNA splicing control through the phosphorylation of the SR protein family of splicing factors. Over the last years, several studies have shown the relevance of SRPK for human cancers and their potential as promising drug targets. In this context, we have previously selected three trifluoromethyl arylamides (named here as SRVIC24, SRVIC30 and S...
Extracellular nucleotide metabolism in Leishmania: influence of adenosine in th...
Fietto, Juliana Lopes Rangel; Marques-da-Silva, Eduardo de Almeida; Oliveira, Jamile Camargos de; Figueiredo, Amanda Braga; Lima Júnior, Djalma de SouzaLeishmaniasis is a parasitic disease with a variety of clinical forms, which are related to the Leishmania species involved. In the murine model, Leishmania amazonensis causes chronic non-healing lesions in Leishmania braziliensis- or Leishmania major-resistant mouse strains. In this study, we investigated the involvement of the pathway of extracellular nucleotide hydrolysis, with special focus on the role of e...
Lipophosphoglycan 3 from leishmania infantum chagasi binds heparin with micromo...
Marques-da-Silva, Eduardo de Almeida
Lipophosphoglycan 3 From Leishmania infantum chagasi Binds Heparin With Micromo...
Martins, Thaís Viana Fialho; Zeraik, Ana Eliza; Alves, Natália Oliveira; Oliveira, Leandro Licursi de; Mendes, Tiago Antônio de OliveiraLeishmania infantum chagasi is an intracellular protozoan parasite responsible for visceral leishmaniasis, a fatal disease in humans. Heparin-binding proteins (HBPs) are proteins that bind to carbohydrates present in glycoproteins or glycolipids. Evidence suggests that HBPs present on Leishmania surface participate in the adhesion and invasion of parasites to tissues of both invertebrate and vertebrate hosts. I...