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Sustained kidney biochemical derangement in treated experimental diabetes : a c...

Oliveira, Antônio Anax Falcão de; Oliveira, Tiago Franco de; Bobadilla, Larissa Letícia; Garcia, Camila Carrião Machado; Berra, Carolina Maria

The occurrence of biochemical alterations that last for a long period of time in diabetic individuals even after adequate handling of glycemia is an intriguing phenomenon named metabolic memory. In this study, we show that a kidney pathway is gradually altered during the course of diabetes and remains persistently changed after late glycemic control in streptozotocin-induced diabetic rats. This pathway comprise...

Date: 2017   |   Origin: Oasisbr


Persistent hypertension and progressive renal injury induced by salt overload a...

Mattar, Ana Lúcia; Machado, Flávia Gomes; Fujihara, Clarice Kazue; Malheiros, Denise Maria Avancini Costa; Zatz, Roberto

INTRODUCTION: Administration of the NO inhibitor Nwð-nitro-L-arginine methyl ester (NAME) and a high-salt diet (HS) promotes severe albuminuria and renal injury, which regresses upon discontinuation of treatments. OBJECTIVE: We investigated whether these changes reappear after reinstitution of HS, and whether they are prevented by treatment with the antilymphocyte agent mycophenolate mofetil (MMF) or the AT-1 r...

Date: 2007   |   Origin: Oasisbr

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