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Socioeconomic disparities in changes to preterm birth and stillbirth rates duri...

Zeitlin, J; Philibert, M; Barros, H; Broeders, L; Cap, J; Draušnik, Ž; Engjom, H; Farr, A; Fresson, J; Gatt, M; Gissler, M; Heller, G; Isakova, J

Background: Despite concerns about worsening pregnancy outcomes resulting from healthcare restrictions, economic difficulties and increased stress during the COVID-19 pandemic, preterm birth (PTB) rates declined in some countries in 2020, while stillbirth rates appeared stable. Like other shocks, the pandemic may have exacerbated existing socioeconomic disparities in pregnancy, but this remains to be establishe...


Variation in follow-up for children born very preterm in Europe

Seppänen, AV; Barros, H; Draper, ES; Petrou, S; Andronis, L; Kim, S; Maier, RF; Pedersen, P; Gadzinowski, J; Pierrat, V; Sarrechia, I; Lebeer, J

Background Children born very preterm (<32 weeks of gestation) face high risks of neurodevelopmental and health difficulties compared with children born at term. Follow-up after discharge from the neonatal intensive care unit is essential to ensure early detection and intervention, but data on policy approaches are sparse. Methods We investigated the characteristics of follow-up policy and programmes in 11 Euro...


Health-related quality of life at 5 years of age for children born very preterm...

Kim, SW; Tian, X; Andronis, L; Maier, RF; Varendi, H; Seppänen, A-V; Siljehav, V; Draper, ES; Zeitlin, J; Petrou, S; Seppänen, AV; El Rafei, R

Background: This study aimed to investigate the health-related quality of life (HRQoL) at 5 years of age of European children born very preterm across multi-dimensional outcomes by presence and severity of congenital anomalies. Methods: The study used data from a European cohort of children born very preterm (<32 weeks of gestation) and followed up to 5 years of age (N = 3493). Multilevel Ordinary Least Squares...


Associations of language barriers with very preterm children's behavioural and ...

Jaekel, J; Aubert, AM; Jaekel, N; Costa, R; Johnson, S; Zeitlin, J; SHIPS Research group

Background: Very preterm birth (<32 weeks gestation, VP), immigrant background, and language barriers are all independently associated with a high risk for mental health problems in childhood, but research has neglected the long-term development of immigrant children born VP. We assessed whether behavioural and socio-emotional problems of 5-year-old children born VP growing up across different language contexts...


Developmental motor problems and health-related quality of life in 5-year-old c...

Aubert, AM; Costa, R; Johnson, S; Ådén, U; Pierrat, V; Cuttini, M; Männamaa, M; Sarrechia, I; Lebeer, J; Van Heijst, AF; Maier, RF; Sentenac, M

Aim To measure the association between cerebral palsy (CP) and non-CP-related movement difficulties and health-related quality of life (HRQoL) among 5-year-old children born extremely preterm (<28 weeks gestational age). Method We included 5-year-old children from a multi-country, population-based cohort of children born extremely preterm in 2011 to 2012 in 11 European countries (n = 1021). Children without CP ...


Prediction of movement difficulties at 5 years from parent report at 2 years in...

Costa, R; Aubert, AM; Seppänen, AV; Ådén, U; Sarrechia, I; Zemlin, M; Cuttini, M; Männamaa, M; Pierrat, V; van Heijst, A; Barros, H; Zeitlin, J

AimTo assess the predictive validity of parent-reported gross motor impairment (GMI) at age 2 years to detect significant movement difficulties at age 5 years in children born extremely preterm. MethodData were from 556 children (270 males, 286 females) born at less than 28 weeks' gestation in 2011 to 2012 in 10 European countries. Parent report of moderate/severe GMI was defined as walking unsteadily or unable...


Risk factors for cerebral palsy and movement difficulties in 5-year-old childre...

Aubert, AM; Costa, R; Johnson, S; Aden, U; Cuttini, M; Koopman-Esseboom, C; Lebeer, J; Varendi, H; Zemlin, M; Pierrat, V; Zeitlin, J

BackgroundMotor impairment is common after extremely preterm (EPT, <28 weeks' gestational age (GA)) birth, with cerebral palsy (CP) affecting about 10% of children and non-CP movement difficulties (MD) up to 50%. This study investigated the sociodemographic, perinatal and neonatal risk factors for CP and non-CP MD.MethodsData come from a European population-based cohort of children born EPT in 2011-2012 in 11 c...


Follow-up after very preterm birth in Europe

Seppänen, AV; Draper, ES; Petrou, S; Barros, H; Andronis, L; Kim, SW; Maier, RF; Pedersen, P; Gadzinowski, J; Lebeer, J; Ådén, U; Toome, L

Follow-up programmes aim to detect neurodevelopmental and health problems and enable early interventions for children born very preterm (<32 weeks of gestational age (GA)). Although the importance of postdischarge follow-up is widely acknowledged, recommendations differ regarding eligibility criteria, frequency, duration and content, especially for follow-up beyond early childhood.1–3 We used data from a Europe...


Never-breastfed children face a higher risk of suboptimal cognition at 2 years ...

Rodrigues, C; Zeitlin, J; Zemlin, M; Wilson, E; Pedersen, P; Barros, H

In a cohort of children born very preterm (VPT), we investigated the association between breast milk feeding (BMF) initiation and its duration on cognitive development at 2 years of corrected age. Data were obtained from the Effective Perinatal Intensive Care in Europe population-based prospective cohort of children born <32 weeks of gestation, in 11 European countries, in 2011–2012. The study sample included 4...


Motor-related health care for 5-year-old children born extremely preterm with m...

Costa, R; Aubert, AM; Seppänen, A-V; Ådén, U; Sarrechia, L; Zemlin, M; Cuttini, M; Männamaa, M; Pierrat, V; van Heijst, A; Barros, H; Johnson, S

Aim: To (1) determine the proportion of 5-year-old children born extremely preterm (EPT) with movement difficulties including cerebral palsy (CP) and the proportion of these children receiving motor-related health care (MRHC), and (2) describe factors associated with receiving MRHC. Method: Children born before 28 weeks’ gestation in 2011 to 2012 in 11 European countries were assessed with the Movement Assessme...


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