2 documents found, page 1 of 1
Influence of lysosomal protease sensitivity in the immunogenicity of the antitu...
Rodrigues, Mariane A.D.; Pimenta, Marcela V.; Costa, Iris M.; Zenatti, Priscila P.; Migita, Natacha A.; Yunes, José A.; Rangel-Yagui, Carlota O.Made available in DSpace on 2021-06-25T10:35:17Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-12-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Ministério da Ciência, Tecnologia, Inovações e Comunicações; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); L-asparaginase (ASNase) from Escherichia ...
Interleukin-7 receptor α mutational activation can initiate precursor B-cell ac...
Almeida, Afonso; Neto, João Luís; Cachucho, Ana; Euzébio, Mayara; Meng, Xiangyu; Kim, Rathana; Fernandes, Marta; Raposo, Beatriz; Oliveira, Mariana L.Interleukin-7 receptor α (encoded by IL7R) is essential for lymphoid development. Whether acute lymphoblastic leukemia (ALL)-related IL7R gain-of-function mutations can trigger leukemogenesis remains unclear. Here, we demonstrate that lymphoid-restricted mutant IL7R, expressed at physiological levels in conditional knock-in mice, establishes a pre-leukemic stage in which B-cell precursors display self-renewal a...