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Extracellular aggregated alpha synuclein primarily triggers lysosomal dysfuncti...

Hoffmann, Anna Carin; Minakaki, Georgia; Menges, Stefanie; Salvi, Rachele; Savitskiy, Sergey; Kazman, Aida; Vicente Miranda, Hugo; Mielenz, Dirk

Cell-to-cell propagation of aggregated alpha synuclein (aSyn) has been suggested to play an important role in the progression of alpha synucleinopathies. A critical step for the propagation process is the accumulation of extracellular aSyn within recipient cells. Here, we investigated the trafficking of distinct exogenous aSyn forms and addressed the mechanisms influencing their accumulation in recipient cells....

Date: 2019   |   Origin: Repositório Institucional da UNL
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Erratum to

Klionsky, Daniel J.; Abdelmohsen, Kotb; Abe, Akihisa; Abedin, Md Joynal; Abeliovich, Hagai; Arozena, Abraham Acevedo; Adachi, Hiroaki

Date: 2016   |   Origin: Repositório Institucional da UNL
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