3 documents found, page 1 of 1
M2-polarized macrophages promote metastatic behavior of Lewis lung carcinoma ce...
Zhang, Bicheng; Zhang, Yafei; Yao, Guoqing; Gao, Juan; Yang, Bo; Zhao, Yong; Rao, Zhiguo; Gao, JianfeiOBJECTIVES: Tumor-associated macrophages that generally exhibit an alternatively activated (M2) phenotype have been linked to tumor progression and metastasis. However, the role of M2-polarized macrophages in the growth and metastasis of lung adenocarcinoma remains enigmatic. The aim of this study was to explore the effect of M2 macrophages on the proliferation and migration of mouse Lewis lung carcinoma cells ...
Synergistic growth inhibition by sorafenib and vitamin K2 in human hepatocellul...
Zhang, Yafei; Zhang, Bicheng; Zhang, Anran; Zhao, Yong; Zhao, Jie; Liu, Jian; Gao, Jianfei; Fang, Dianchun; Rao, ZhiguoOBJECTIVE: Sorafenib is an oral multikinase inhibitor that has been proven effective as a single-agent therapy in hepatocellular carcinoma, and there is a strong rationale for investigating its use in combination with other agents. Vitamin K2 is nearly non-toxic to humans and has been shown to inhibit the growth of hepatocellular carcinoma. In this study, we evaluated the effects of a combination of sorafenib a...
M2-Polarized tumor-associated macrophages are associated with poor prognoses re...
Zhang, Bicheng; Yao, Guoqing; Zhang, Yafei; Gao, Juan; Yang, Bo; Rao, Zhiguo; Gao, JianfeiOBJECTIVES: Tumor-associated macrophages have been implicated in promoting tumor growth, progression and metastasis. However, the activated phenotype (M1 or M2) of tumor-associated macrophages remains unknown in solid tumors. Therefore, this study examined the density and prognostic significance of M2-polarized tumor-associated macrophages in lung adenocarcinoma. METHODS: Tumor specimens from 65 lung adenocarci...