4 documents found, page 1 of 1
Somatic CAG repeat expansion in blood associates with biomarkers of neurodegene...
Scahill, Rachael I.; Farag, Mena; Murphy, Michael J.; Hobbs, Nicola Z.; Leocadi, Michela; Langley, Christelle; Knights, Harry; Ciosi, Marc; Fayer, KateHuntington's disease (HD) is an autosomal dominant neurodegenerative disease with the age at which characteristic symptoms manifest strongly influenced by inherited HTT CAG length. Somatic CAG expansion occurs throughout life and understanding the impact of somatic expansion on neurodegeneration is key to developing therapeutic targets. In 57 HD gene expanded (HDGE) individuals, ~23 years before their predicted...
Experimental yellow fever virus infection in the golden hamster (Mesocricetus a...
Tesh, Robert B; Guzman, Hilda; Rosa, Am?lia Paes de Andrade Travassos da; Vasconcelos, Pedro Fernando da Costa; Dias, Leonidas B; Bunnell, Joseph EUniversity of Texas Medical Branch. Department of Pathology. Center for Tropical Diseases. Galveston, USA.; University of Texas Medical Branch. Department of Pathology. Center for Tropical Diseases. Galveston, USA.; University of Texas Medical Branch. Department of Pathology. Center for Tropical Diseases. Galveston, USA.; Minist?rio da Sa?de. Funda??o Nacional de Sa?de. Instituto Evandro Chagas. Bel?m, PA, Bras...
Journals on legal and forensic medicine in Web of Science Core Collection: focu...
Zhang, Hui; Vieira, Duarte Nuno; Shen, Min
Icariin stimulates differentiation of bone marrow-derived mesenchymal stem cell...
Lou, Dan; Ye, Jifeng; Yang, Lianhua; Wu, Zheng; Zheng, Wei; Zhang, HuiIcariin, a prenylated flavonol glycoside isolated from Epimedium, has been considered as a potential alternative therapy for osteoporosis. The present study aimed to clarify the detailed molecular mechanisms of action of icariin on osteoblast function, using bone marrow-derived mesenchymal stem cells (BM‑MSCs). BM-MSCs were first stimulated by icariin. Then, gene and protein expression of cAMP/ PKA/CREB signali...