5 documents found, page 1 of 1
Impact of heat on emergency hospital admissions related to kidney diseases in T...
Guo, Chunyu; Ge, Erjia; Yu, Manzhu; Li, Changwei; Lao, Xiangqian; Li, Shuang; Glaser, Jason; He, Yongqun; Almeida-Silva, Marina; Meng, SisiBackground and objective: While the impact of heat exposure on human health is well-documented, limited research exists on its effect on kidney disease hospital admissions, especially in Texas, a state with diverse demographics and a high heat-related death rate. We aimed to explore the link between high temperatures and emergency kidney disease hospital admissions across 12 Texas Metropolitan Statistical Areas...
Smart mitochondria-specific anchored gold-based nanosystem for integration of t...
Yin, Xuelian; Zhan, Lin; Ding, Lin; Chen, Xuerui; Zhang, Junfeng; Li, Chenchen; Zhang, Yuxi; Khan, Murad; Reis, R. L.; Wang, YanliAlthough recent advances have been made in improving the efficacy of photodynamic therapy, efficient therapeutic approaches based on reactive oxygen species (ROS) are needed, particularly mitochondria-specific targeting of nanomaterials that can alter the internal environment of organelles. Herein, we report the facile synthesis of mitochondria-specific anchored nano-complexes (AG-CNP) comprised of a skeleton o...
Design strategies of tumor-targeted delivery systems based on 2D nanomaterials
Ding, Lin; Liang, Minli; Li, Chenchen; Ji, Xinting; Zhang, Junfeng; Xie, Weifen; Reis, R. L.; Li, Fu-Rong; Gu, Shuo; Wang, YanliConventional chemotherapy and radiotherapy are nonselective and nonspecific for cell killing, causing serious side effects and threatening the lives of patients. It is of great significance to develop more accurate tumor-targeting therapeutic strategies. Nanotechnology is in a leading position to provide new treatment options for cancer, and it has great potential for selective targeted therapy and controlled d...
A multifunctional photoacoustic/fluorescence dual-mode-imaging gold-based thera...
Zhang, Junfeng; Yin, Xiaofeng; Li, Chenchen; Yin, Xuelian; Xue, Qianghua; Ding, Lin; Ju, Jiale; Ma, Jifei; Zhu, Ying; Du, Dongshu; Reis, R. L.Theranostics is a new type of biomedical technology that organically combines the diagnosis and therapy of diseases. Among molecular imaging techniques, the integration of photoacoustic (PA) and fluorescence (FL) imaging modes with high sensitivity and imaging depth provides precise diagnostic outcomes. Gold nanorods (Au NRs) are well-known contrast agents for PA imaging and photothermal therapy. However, their...
Organelle-specific anchored delivery system stretching a reversal of tumor hypo...
Chen, Xuerui; Yin, Xuelian; Zhan, Lin; Zhang, Junfeng; Zhang, Yuxi; Wu, Yinghua; Ju, Jiale; Li, Yajie; Xue, Qianghua; Wang, Xu; Li, ChenchenDirect delivery to an organelle-specific point can boost the efficacy of therapy procedures to new heights. Among other subcellular organelles, mitochondria generate ATP as intracellular powerhouse, and are associated with multiple aspects of tumorigenesis and tumor development. Here, a mitochondrial anchored biomimetic nanoplatform (CZACN) is designed and its reversal of tumor hypoxia microenvironment underlyi...