4 documents found, page 1 of 1
The Highly Potent AhR Agonist Picoberin Modulates Hh-Dependent Osteoblast Diffe...
Flegel, J; Shaaban, S; Jia, ZJ; Schulte, B; Lian, Y; Krzyzanowski, A; Metz, M; Schneidewind, T; Wesseler, F; Flegel, A; Reich, A; Brause, A; Xue, GIdentification and analysis of small molecule bioactivity in target-agnostic cellular assays and monitoring changes in phenotype followed by identification of the biological target are a powerful approach for the identification of novel bioactive chemical matter in particular when the monitored phenotype is disease-related and physiologically relevant. Profiling methods that enable the unbiased analysis of comp...
Left-right side-specific endocrine signaling complements neural pathways to med...
Lukoyanov, NV; Watanabe, H; Carvalho, LS; Kononenko, O; Sarkisyan, D; Zhang, M; Andersen, MS; Lukoyanova, EA; Galatenko, V; Tonevitsky, A; Bazov, IBrain injuries can interrupt descending neural pathways that convey motor commands from the cortex to spinal motoneurons. Here, we demonstrate that a unilateral injury of the hindlimb sensorimotor cortex of rats with completely transected thoracic spinal cord produces hindlimb postural asymmetry with contralateral flexion and asymmetric hindlimb withdrawal reflexes within 3 hr, as well as asymmetry in gene expr...
Left-right side-specific neuropeptide mechanism mediates contralateral response...
Watanabe, H; Nosova, O; Sarkisyan, D; Andersen, MS; Carvalho, LS; Galatenko, V; Bazov, I; Lukoyanov, NV; Maia, GH; Hallberg, M; Zhang, M; Schouenborg, JNeuropeptides are implicated in control of lateralized processes in the brain. A unilateral brain injury (UBI) causes the contralesional sensorimotor deficits. To examine whether opioid neuropeptides mediate UBI induced asymmetric processes we compared effects of opioid antagonists on the contralesional and ipsile-sional hindlimb responses to the left-sided and right-sided injury in rats. UBI induced hindlimb p...
Hierarchical structured and programmed vehicles deliver drugs locally to inflam...
Li, W; Li, Y; Liu, Z; Kerdsakundee, N; Zhang, M; Zhang, F; Liu, X; Bauleth-Ramos, T; Lian, W; Mäkilä, E; Kemell, M; Ding, Y; Sarmento, BOrally administrable drug delivery vehicles are developed to manage incurable inflammatory bowel disease (IBD), however, their therapeutic outcomes are compromised by the side effects of systemic drug exposure. Herein, we use hyaluronic acid functionalized porous silicon nanoparticle to bridge enzyme-responsive hydrogel and pH-responsive polymer, generating a hierarchical structured (nano-in-nano-in-micro) vehi...