8 documents found, page 1 of 1
Modulation of chronic obstructive pulmonary disease progression by antioxidant ...
Liu, Yiting; Li, Longjie; Feng, Jing; Wan, Bing; Tu, Qiang; Cai, Wei; Jin, Fa; Tang, Guiying; Rodrigues, L. R.; Zhang, Xiuwei; Yin, Jia; Zhang, YunleiChronic obstructive pulmonary disease (COPD), a condition primarily linked to oxidative stress, poses significant health burdens worldwide. Recent evidence has shed light on the association between the dysbiosis of gut microbiota and COPD, and their metabolites have emerged as potential modulators of disease progression through the intricate gut-lung axis. Here, we demonstrate the efficacy of oral administratio...
Protein-assisted synthesis of chitosan-coated minicells enhance dendritic cell ...
Rodrigues, L. R.; Feng, Jing; Liu, Yiting; Zheng, Xiaoran; Gao, Min; Wang, Li; Wen, Yuting; Pan, Hangcheng; Li, Gege; Zhang, Longjiang; Wan, BingThe efficacy of cancer therapies is significantly compromised by the immunosuppressive tumor milieu. Herein, we introduce a previously unidentified therapeutic strategy that harnesses the synergistic potential of chitosan-coated bacterial vesicles and a targeted chemotherapeutic agent to activate dendritic cells, thereby reshaping the immunosuppressive milieu for enhanced cancer therapy. Our study focuses on th...
Editorial: Microorganisms and their derivatives for cancer therapy
Zhang, Yunlei; Rodrigues, L. R.; Cao, Zhenping; Li, Juanjuan[Execerpt] Cancer remains an unsolved and challenging problem. In 1890, Dr. William Bradley Coley attempted to use a mixture of dead microbes to treat cancers (Dobosz and Dzieciatkowski, 2019; Liu et al., 2022), establishing the foundation of bacteria-mediated cancer therapy. Given the recent advances in the study of the human microbiome that revealed its crucial role in tumorigenesis, development, therapy, and...
Acid-directed electrostatic self-assembly generates charge-reversible bacteria ...
Feng, Jing; Liu, Yiting; Pan, Xia; Jin, Fa; Wu, Liangquan; Chen, Jianquan; Wan, Bing; Zhang, Xiuwei; Rodrigues, L. R.; Zhang, YunleiDespite recent preclinical progress with oncolytic bacteria in cancer therapy, dose-limiting toxicity has been a long-standing challenge for clinical application. Genetic and chemical modifications for enhancing the bacterial tumor-targeting ability have been unable to establish a balance between increasing its specificity and effectiveness while decreasing side effects. Herein, we report a simple, highly effic...
In vitro evaluation of bovine lactoferrin potential as an anticancer agent
Zhang, Yunlei; Lima, Cristóvão F.; Rodrigues, L. R."Available online 2 September 2014"; Bovine lactoferrin (bLF) was shown to efficiently inhibit the growth of MCF-7, T-47D, MDA-MB-231 and Hs578T breast cancer cells in a concentration-dependent manner. However, apoptosis was only induced in MCF-7 cells, which was associated with the mitochondria membrane depolarisation and a decrease of Bcl-2 levels. bLF led to the cycle arrest of MCF-7 cells at G1/G0 phase, as...
Anticancer effects of lactoferrin: underlying mechanisms and future trends in c...
Zhang, Yunlei; Lima, Cristóvão F.; Rodrigues, L. R.Lactoferrin has been widely studied over the last 70 years, and its role in diverse biological functions is now well known and generally accepted by the scientific community. Usually, alterations of the lactoferrin gene in cells are associated with an increased incidence of cancer. Several studies suggest that exogenous treatment with lactoferrin and its derivatives can efficiently inhibit the growth of tumors ...
Bovine lactoferrin induces cell cycle arrest and inhibits mTOR signaling in bre...
Zhang, Yunlei; Nicolau, Ana; Lima, Cristóvão F.; Rodrigues, L. R.Lactoferrin (LF) is predominantly found in mammalian secretions with recognized anticancer potential, although the mechanisms involved in such activity are still unclear. Here, the stability, internalization, and cytotoxicity of bovine LF (bLF) and its variants were tested against a panel of breast cancer cells. bLF was found to be very stable under incubation with cells and also able to internalize them, altho...
Study of the mechanisms underlying the cytotoxic effects of bovine lactoferrin ...
Zhang, YunleiTese de doutoramento em Engenharia Biomédica; Lactoferrin (LF) is an iron-binding protein predominantly found in mammalian secretions. This protein and its variants have been proposed for cancer therapy for many years owing to their tumor-targeting properties. Previous studies showed that LF and its derived peptides inhibit the proliferation of cancer cells. However, the detailed mechanisms by which LF exerts i...