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Antheraea pernyi silk nanofibrils with inherent RGD motifs accelerate diabetic ...

Duan, Lian; Liu, Ga; Liao, Fuying; Xie, Chunyu; Shi, Jiahao; Yang, Xiao; Zheng, Fan; Reis, R. L.; Kundu, Subhas C; Xiao, Bo

The chronic inflammation and matrix metalloprotease (MMP)-induced tissue degradation significantly disrupt re-epithelization and delay the healing process of diabetic wounds. To address these issues, we produced nanofibrils from Antheraea pernyi (Ap) silk fibers via a facile and green treatment of swelling and shearing. The integrin receptors on the cytomembrane could specifically bind to the Ap nanofibrils (Ap...


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