9 documents found, page 1 of 1
Chemical composition and biological properties of Ipomoea procumbens
Batiga,Saadia; Valli,Marilia; Zeraik,Maria L.; Fraige,Karina; Leme,Gabriel M.; Pitangui,Nayla S.; Almeida,Ana Marisa F.; Michel,SylvieABSTRACT Natural products have been the most valuable source of chemical compounds in the discovery of novel medicines. Secondary metabolites from terrestrial and marine organisms have found considerable use in the treatment of numerous diseases and have been considered lead molecules both in their natural form and as templates for medicinal chemistry. Brazil has an exceptionally rich biodiversity, and a valuab...
ISOLATION OF ANTIFUNGAL QUINOID DERIVATIVES FROM LEAVES OF Pentacalia desiderab...
Gomes,Kaio de S.; Tamayose,Cinthia I.; Ferreira,Marcelo José P.; Murakami,Cynthia; Young,Maria Claudia M.; Antar,Guilherme M.; Camilo,Fernanda F.In the present work, leaves of Pentacalia desiderabilis (Asteraceae) were subjected to extraction using aqueous 1-butyl-3-methylimidazolium bromide (BMImBr) in the microwave assisted extraction (MAE). The obtained extract was partitioned using CH2Cl2 and antifungal activity against Cladosporium cladosporioides and C. sphaerospermum of the organic phase was evaluated. Sequentially, this material was subjected to...
Citocalasinas produzidas por Xylaria sp., um fungo endofítico de Piper aduncum ...
Silva,Geraldo H.; Oliveira,Camila M. de; Teles,Helder L.; Bolzani,Vanderlan da S.; Araujo,Angela R.; Pfenning,Ludwig H.; Young,Maria Claudia M.A chemical study on the EtOAc extract produced by Xylaria sp., an endophytic fungus from Piper aduncum, resulted in the isolation of a new cytochalasin 1, along with five known 19,20-epoxycytochalasin D (2), C (3), N (4), Q (5), and R (6). The 1-6 were evaluated against the fungi C. cladosporioides and C. sphaerospermum and only 5 showed weak activity. The cytotoxicity in vitro against HeLA and CHO cells lines ...
Biciclogermacreno, resveratrol e atividade antifúngica em extratos de folhas de...
Silva,Luciana da; Oniki,Glaucia H.; Agripino,Débora G.; Moreno,Paulo R. H.; Young,Maria Claudia M.; Mayworm,Marco Aurélio S.; Ladeira,Angela M.Cissus verticillata L. (Vitaceae) tem sido empregada popularmente como anti-diabética. Nessa espécie foi também detectada atividade fungitóxica. O objetivo do presente trabalho foi realizar a identificação dos compostos fungitóxicos em extratos de folhas. O extrato etanólico foi submetido a fracionamento com solventes de diferentes polaridades (hexano, clorofórmio, acetato de etila e butanol) e seu efeito antif...
Antifungal derivatives from Piper mollicomum and P. lhotzkyanum (Piperaceae)
Lago,João Henrique G.; Young,Maria Claudia M.; Reigada,Juliana B.; Soares,Marisi G.; Roesler,Bianca P.; Kato,Massuo J.Bioguided fractionation of the extracts from leaves of Piper mollicomum and Piper lhotzkyanum against the fungi Cladosporium cladosporioides and C. sphaerospermum afforded seven bioactive compounds, four being chromenes: methyl 2,2-dimethyl-2H-chromene-6-carboxylate, methyl 8-hydroxy-2,2-dimethyl-2H-chromene-6-carboxylate, 2-methyl-2-[4'-methyl-3'-pentenyl]-2H-1-benzopyran-6-carboxylic acid, 2,2-dimethyl-2H-chr...
Electrospray ionization mass spectrometry screening of piperidine alkaloids fro...
Pivatto,Marcos; Crotti,Antônio E. M.; Lopes,Norberto P.; Castro-Gamboa,Ian; Rezende,Amanda de; Viegas Jr.,Cláudio; Young,Maria Claudia M.; Furlan,MaysaThe fragmentation pattern of a homologous series of piperidine alkaloids isolated from S. spectabilis was investigated using electrospray ionization tandem mass spectrometry (ESI-MS/MS). The ESI-MS and ESI-MS/MS analyses of EtOH extracts and fractions from flowers and fruits of S. spectabilis allowed to elucidate the structures of four new compounds. The identification of these co-metabolites, based on the frag...
Antifungal piperolides from Piper malacophyllum (Prels) C. DC.
Lago,João Henrique G.; Tanizaki,Tatiane M.; Young,Maria Claudia M.; Guimarães,Elsie F.; Kato,Massuo J.Bioactivity-guided fractionation of the CH2Cl2 extract from leaves of Piper malacophyllum using bioautography assay against fungi, led to the isolation of two known bioactive piperolides: 4,6-dimethoxy-5-E-phenylbutenolide (1) and 4,6-dimethoxy-5-Z-phenylbutenolide (2). IR, MS and NMR spectroscopic data were used for the identification of these compounds including comparison with previously reported data. The E...
Estudo fitoquímico e avaliação da atividade moluscicida da Kielmeyera variabili...
Pinheiro,Lucimar; Cortez,Diógenes Aparício Garcia; Vidotti,Gentil J.; Young,Maria Claudia M.; Ferreira,Antônio GilbertoMethanol extract obtained from Kielmeyera variabilis stems showed significant molluscicidal activity against Biomphalaria glabrata. The phytochemical studies of the plants stem to the isolation of three xanthones (assiguxanthone-B, kielcorin and 1,3,5,6-tetrahtydroxy-2-prenylxanthone) and a organic acid (2,5-dihydroxy benzoic acid). The structures of these compounds were identified by IR, MS, ¹H and 13C NMR spe...
Complete Assignments of ¹H and 13C-NMR Spectra of the 3,4-seco-Triterpene Canar...
Lopes,Marcia N.; Mazza,Fabiano C.; Young,Maria Claudia M.; Bolzani,Vanderlan da S.The canaric acid 1 was isolated from the leaves of Rudgea jasminoides. Compound 1 is a seco-lupane derivative and its structure was established on the basis of spectral data, mainly by 1D and 2D NMR experiments. Sitosterol, stigmasterol and ursolic and oleanolic acids were also isolated.