13 documents found, page 1 of 2
Encapsulation of Active Pharmaceutical Ingredients in Lipid Micro/Nanoparticles...
Favaro-Trindade, Carmen S.; Matos Junior, Fernando E. de; Okuro, Paula K.; Dias-Ferreira, João; Cano, Amanda; Severino, Patricia; Zielińska, AleksandraNanoencapsulation via spray cooling (also known as spray chilling and spray congealing) has been used with the aim to improve the functionality, solubility, and protection of drugs; as well as to reduce hygroscopicity; to modify taste and odor to enable oral administration; and many times to achieve a controlled release profile. It is a relatively simple technology, it does not require the use of low-cost solve...
Elastic and Ultradeformable Liposomes for Transdermal Delivery of Active Pharma...
Souto, Eliana; Macedo, Ana S; Dias-Ferreira, João; Cano, Amanda; Zielińska, Aleksandra; Matos, Carla M.Administration of active pharmaceutical ingredients (APIs) through the skin, by means of topical drug delivery systems, is an advanced therapeutic approach. As the skin is the largest organ of the human body, primarily acting as a natural protective barrier against permeation of xenobiotics, specific strategies to overcome this barrier are needed. Liposomes are nanometric-sized delivery systems composed of phos...
Cannabidiol in Neurological and Neoplastic Diseases: Latest Developments on the...
Ożarowski, Marcin; Karpiński, Tomasz M.; Zielińska, Aleksandra; Souto, Eliana B.; Wielgus, KarolinaAs the major nonpsychotropic constituent of Cannabis sativa, cannabidiol (CBD) is regarded as one of the most promising therapeutic agents due to its proven effectiveness in clinical trials for many human diseases. Due to the urgent need for more efficient pharmacological treatments for several chronic diseases, in this review, we discuss the potential beneficial effects of CBD for Alzheimer's disease, epilepsy...
Genotoxicity Assessment of Metal-Based Nanocomposites Applied in Drug Delivery
Cardoso, Sara; da Silva, Classius F; Severino, Patrícia; Silva, Amélia M.; Souto, Selma B; Zielińska, Aleksandra; Karczewski, Jacek; Souto, Eliana B.Nanocomposites as drug delivery systems (e.g., metal nanoparticles) are being exploited for several applications in the biomedical field, from therapeutics to diagnostics. Green nanocomposites stand for nanoparticles of biocompatible, biodegradable and non-toxic profiles. When using metal nanoparticles for drug delivery, the question of how hazardous these "virus-sized particles" can be is posed, due to their n...
Quality by Design Approach for the Development of Liposome Carrying Ghrelin for...
Barros, Cecília de; Aranha, Norberto; Severino, Patrícia; Souto, Eliana B.; Zielińska, Aleksandra; Lopes, André; Rios, Alessandra; Batain, FernandoThe therapeutic use of peptides has increasingly recognized in the development of new therapies. However, the susceptible enzymatic cleavage is a barrier that needs to overcome. Nose-to-brain delivery associated with liposomes can protect peptides against biodegradation and improve the accessibility to brain targets. The aim was to develop a liposomal formulation as ghrelin carrier. The quality by design (QbD) ...
Lipid-Polymeric Films: Composition, Production and Applications in Wound Healin...
Souto, Eliana B.; Yoshida, Cristiana M. P.; Leonardi, Gislaine R.; Cano, Amanda; Sanchez-Lopez, Elena; Zielińska, Aleksandra; Viseras, CésarThe use of lipids in the composition of polymeric-based films for topical administration of bioactive ingredients is a recent research topic; while few products are commercially available, films containing lipids represent a strategic area for the development of new products. Some lipids are usually used in polymeric-based film formulations due to their plasticizing action, with a view to improving the mechanic...
Cancer Nanopharmaceuticals: Physicochemical Characterization and In Vitro/In Vi...
Zielińska, Aleksandra; Szalata, Marlena; Gorczyński, Adam; Karczewski, Jacek; Eder, Piotr; Severino, Patrícia; Cabeda, José M.; Souto, Eliana B.Physicochemical, pharmacokinetic, and biopharmaceutical characterization tools play a key role in the assessment of nanopharmaceuticals' potential imaging analysis and for site-specific delivery of anti-cancers to neoplastic cells/tissues. If diagnostic tools and therapeutic approaches are combined in one single nanoparticle, a new platform called nanotheragnostics is generated. Several analytical technologies ...
Cancer nanopharmaceuticals: physicochemical characterization and in vitro/in vi...
Zielińska, Aleksandra; Szalata, Marlena; Gorczyński, Adam; Karczewski, Jacek; Eder, Piotr; Severino, Patrícia; Cabeda, JM; Souto, Eliana B.Physicochemical, pharmacokinetic, and biopharmaceutical characterization tools play a key role in the assessment of nanopharmaceuticals’ potential imaging analysis and for site-specific delivery of anti-cancers to neoplastic cells/tissues. If diagnostic tools and therapeutic approaches are combined in one single nanoparticle, a new platform called nanotheragnostics is generated. Several analytical technologies ...
(+)-Limonene 1,2-Epoxide-Loaded SLNs: Evaluation of Drug Release, Antioxidant A...
Souto, Eliana B.; Zielińska, Aleksandra; Souto, Selma B; Durazzo, Alessandra; Lucarini, Massimo; Santini, Antonello; Atanasov, Atanas G.In this work, we developed a solid lipid nanoparticle (SLN) formulation with (+)-limonene 1,2-epoxide and glycerol monostearate (Lim-SLNs), stabilized with Poloxamer® 188 in aqueous dispersion to modify the release profile of the loaded monoterpene derivative. We also evaluated the role of SLNs in lipid peroxidation and cytotoxicity in a spontaneously transformed aneuploid immortal keratinocyte cell line from a...
Chemical and Physical Properties of Meadowfoam Seed Oil and Extra Virgin Olive ...
Zielińska, Aleksandra; Wójcicki, Krzysztof; Klensporf-Pawlik, Dorota; Dias-Ferreira, João; Lucarini, Massimo; Durazzo, Alessandra; Lucariello, GiuseppeIn food industry, vegetable oils are commonly used as functional ingredients. Cold pressed oils containing fatty acids show a variety of chemical properties, which are mainly dependent on the saturation of fatty acids. In this study, we have analyzed meadowfoam seed oil (MSO), obtained from seeds of Limnanthes alba, and extra virgin olive oil (EVO). Firstly, the fatty acids composition, denoted as Cox value, wa...