5 documents found, page 1 of 1
A hint for the obesity paradox and the link between obesity, perirenal adipose ...
Preza-Fernandes, J; Passos, P; Mendes-Ferreira, M; Rodrigues, AR; Gouveia, Alexandra; Fraga, A; Medeiros, R; Ribeiro, RIncreasing evidence supports a role for local fat depots in cancer outcomes. Despite the robust positive association of obesity with renal cell carcinoma (RCCa) diagnosis, increased adiposity is inversely related to RCCa oncological outcomes. Here, we sought to ascertain whether imagiologically assessed local fat depots associate with RCCa progression and survival and account for this apparent paradox. A retros...
Urinary biomarkers in bladder cancer: Where do we stand and potential role of e...
Oliveira, MC; Caires, HR; Oliveira, MJ; Fraga, A; Vasconcelos, MH; Ribeiro, RExtracellular vesicles (EVs) are small membrane vesicles released by all cells and involved in intercellular communication. Importantly, EVs cargo includes nucleic acids, lipids, and proteins constantly transferred between different cell types, contributing to autocrine and paracrine signaling. In recent years, they have been shown to play vital roles, not only in normal biological functions, but also in pathol...
Epigenome-wide DNA methylation profiling of periprostatic adipose tissue in pro...
Cheng, Y; Monteiro, C; Matos, M; You, J; Fraga, A; Pereira, C; Catalán, V; Rodríguez, A; Gómez-Ambrosi, J; Frühbeck, G; Ribeiro, R; Hu, PBackground: Periprostatic adipose tissue (PPAT) has been recognized to associate with prostate cancer (PCa) aggressiveness and progression. Here, we sought to investigate whether excess adiposity modulates the methylome of PPAT in PCa patients. DNA methylation profiling was performed in PPAT from obese/overweight (OB/OW, BMI > 25 kg m-2) and normal weight (NW, BMI < 25 kg m-2) PCa patients. Significant differen...
The HIF1A Functional Genetic Polymorphism at Locus +1772 Associates with Progre...
Fraga, A; Ribeiro, R; Príncipe, P; Lobato, C; Pina, F; Maurício, J; Monteiro, C; Sousa, H; Calais da Silva, F; Lopes, C; Medeiros, RThe hypoxia inducible factor 1 alpha (HIF1a) is a key regulator of tumour cell response to hypoxia, orchestrating mechanisms known to be involved in cancer aggressiveness and metastatic behaviour. In this study we sought to evaluate the association of a functional genetic polymorphism in HIF1A with overall and metastatic prostate cancer (PCa) risk and with response to androgen deprivation therapy (ADT). The HIF...
Churg-Strauss syndrome: a disabling disease.
André, M C; Fraga, A; Reis, M Duarte; Filipe, P; Soares de Almeida, L M; Marques Gomes, M AChurg-Strauss syndrome (CSS) is an infrequent vasculitis that affects small to medium-sized vessels. We describe a 51 year-old-female admitted to our inpatient unit with bullae on her right foot and forearm with pain, paresthesias and impotence of the foot. There was rapid clinical deterioration with lost of gait and peripheral eosinophilia. Histopathology showed many extravascular eosinophils. Bone marrow had ...