3 documents found, page 1 of 1
Polymorphisms within autophagy-related genes as susceptibility biomarkers for m...
Clavero, Esther; Sanchez-Maldonado, José Manuel; Macauda, Angelica; Ter Horst, Rob; Marques, Maria Belém Sousa Sampaio; Jurczyszyn, ArturMultiple myeloma (MM) arises following malignant proliferation of plasma cells in the bone marrow, that secrete high amounts of specific monoclonal immunoglobulins or light chains, resulting in the massive production of unfolded or misfolded proteins. Autophagy can have a dual role in tumorigenesis, by eliminating these abnormal proteins to avoid cancer development, but also ensuring MM cell survival and promot...
Corrigendum: Genome-wide association study identifies variants at 16p13 associa...
Ziv, Elad; Dean, Eric; Hu, Donglei; Martino, Alessandro; Serie, Daniel; Curtin, Karen; Campa, Daniele; Aftab, Blake; Bracci, Paige; Buda, Gabriele[Excerpt] In this Article, members of the UCSF cohort who had been alive for longer than two years were inadvertently included in the data presented in Table 3. USCF/old treatments should have 109 patients with a hazard ratio of 3.35 and a P value of 0.00028 instead of the 124 patients with a hazard ratio of 3.37 and a P value of 0.00026. The USCF/new patients should have 187 patients with a hazard ratio of 3.5...
Genome-wide association study identifies variants at 16p13 associated with surv...
Ziv, Elad; Dean, Eric; Hu, Donglei; Martino, Alessandro; Serie, Daniel; Curtin, Karen; Campa, Daniele; Aftab, Blake; Bracci, Paige; Buda, GabrieleHere we perform the first genome-wide association study (GWAS) of multiple myeloma (MM) survival. In a meta-analysis of 306 MM patients treated at UCSF and 239 patients treated at the Mayo clinic, we find a significant association between SNPs near the gene FOPNL on chromosome 16p13 and survival (rs72773978; P=6 × 10(-10)). Patients with the minor allele are at increased risk for mortality (HR: 2.65; 95% CI: 1....