10 documents found, page 1 of 1
Nano-armed Limosilactobacillus reuteri for enhanced photo-immunotherapy and mic...
Xu, Haiting; Wang, Yajun; Liu, Ga; Zhu, Zhenhua; Shahbazi, Mohammad-Ali; Reis, R. L.; Kundu, Subhas C; Shi, Xiaoxiao; Zu, Menghang; Xiao, BoDespite being a groundbreaking approach to treating colorectal cancer (CRC), the efficacy of immunotherapy is significantly compromised by the immunosuppressive tumor microenvironment and dysbiotic intestinal microbiota. Here, leveraging the superior carrying capacity and innate immunity-stimulating property of living bacteria, a nanomedicine-engineered bacterium, LR-S-CD/CpG@LNP, with optical responsiveness, i...
Reinforced plant-derived lipid nanoparticles for oral precise epigenome editing...
Gao, Qiang; Gao, Yunxia; Cao, Yingui; Xu, Haiting; Ma, Ya; Zu, Menghang; Yang, Qiang; Yang, Kun; Zhu, Zhenhua; Liu, Chao; Shi, X. X.; Reis, R. L.The clinical application of CRISPR-Cas9 remains limited by delivery challenges, particularly for oral administration. Lysine-specific demethylase 1 (Lsd1) plays a key role in colonic inflammation and tumorigenesis. Here, we developed an oral genome-editing platform (TPGS-RNP@LNP), where Lsd1-targeting ribonucleoproteins (RNPs) were encapsulated in mulberry leaf lipid nanoparticles (LNPs) and formulated with d-α...
Oral oncolytic magnetotactic bacteria elicit anti-colorectal tumor immunity and...
Jiang, Aodi; Li, Baoyi; Zu, Menghang; Chen, Li; Zhao, Chan; Tian, Jiesheng; Reis, R. L.; Kundu, Subhas C; Xiao, Bo; Shi, XiaoxiaoTherapeutic outcomes of colorectal cancer (CRC) are influenced by intestinal microbiota and metabolites. To leverage the tumor-tropism and microbiota-regulating properties of bacteria, we developed oncolytic magnetotactic bacteria (MSR-CPT/APPs) loaded with camptothecin (CPT) and anti-PD-L1 peptide (APP) for targeted chemo-magnetothermal immunotherapy of CRC. To further achieve oral delivery, MSR-CPT/APPs were ...
An oral nanomedicine elicits in situ vaccination effect against colorectal cancer
Zu, Menghang; Ma, Ya; Zhang, Jun; Sun, Jianfeng; Shahbazi, Mohammad-Ali; Pan, Guoqing; Reis, R. L.; Kundu, Subhas C; Liu, Jinyao; Xiao, BoOral administration is the most preferred approach for treating colon diseases, and in situ vaccination has emerged as a promising cancer therapeutic strategy. However, the lack of effective drug delivery platforms hampered the application of in situ vaccination strategy in oral treatment of colorectal cancer (CRC). Here, we construct an oral coreâ shell nanomedicine by preparing a silk fibroin-based dual s...
Oral exosome-like nanovesicles from Phellinus linteus suppress metastatic hepat...
Zu, Menghang; Liu, Ga; Chen, Nanxi; Chen, Li; Gao, Qiang; Reis, R. L.; Kundu, Subhas C; Jin, Meilan; Xiao, Bo; Shi, XiaoxiaoThe biomedical application of nanotechnology in cancer treatment has demonstrated significant potential for improving treatment efficiencies and ameliorating adverse effects. However, the medical translation of nanotechnology-based nanomedicines faces challenges including hazardous environmental effects, difficulties in large-scale production, and possible excessive costs. In the present study, we extracted and...
CaO2-Cu2O micromotors accelerate infected wound healing through antibacterial f...
Liu, Ga; Zu, Menghang; Wang, Lingshuang; Xu, Cheng; Zhang, Jiamei; Reis, R. L.; Kundu, Subhas C; Xiao, Bo; Duan, Lian; Yang, XiaoDuring the wound tissue healing process, the relatively weak driving forces of tissue barriers and concentration gradients lead to a slow and inefficient penetration of bioactive substances into the wound area, consequently showing an impact on the effectiveness of deep wound healing. To overcome these challenges, we constructed biocompatible CaO2–Cu2O “micromotors”. These micromotors reacted with the fluids at...
Natural lipid nanoparticles extracted from Morus nigra L. leaves for targeted t...
Gao, Qiang; Chen, Nanx; Li, Baoyi; Zu, Menghang; Ma, Ya; Xu, Haiting; Zhu, Zhenhua; Reis, R. L.; Kundu, Subhas C; Xiao, BoThe clinical application of conventional medications for hepatocellular carcinoma treatment has been severely restricted by their adverse effects and unsatisfactory therapeutic effectiveness. Inspired by the concept of â medicine food homologyâ , we extracted and purified natural exosome-like lipid nanoparticles (LNPs) from black mulberry (Morus nigra L.) leaves. The obtained MLNPs possessed a desirable hydrod...
Extracellular vesicles from nanomedicine-trained intestinal microbiota substitu...
Zu, Menghang; Liu, Ga; Xu, Haiting; Zhu, Zhenhua; Zhen, Junfeng; Shi, Baoyi; Shahbazi, Mohammad-Ali; Reis, R. L.; Kundu, Subhas C; Nie, GuangjunThe biosafety concerns associated with fecal microbiota transplant (FMT) limit their clinical application in treating ulcerative colitis (UC). Gut microbiota secrete abundant extracellular vesicles (Gm-EVs), which play a critical role in bacteria-to-bacteria and bacteria-to-host communications. Herein, intestinal microbiota are trained using tea leaf lipid/pluronic F127-coated curcumin nanocrystals (CN@Lp127s),...
Magnetic natural lipid nanoparticles for oral treatment of colorectal cancer th...
Li, Baoyi; Zu, Menghang; Jiang, Aodi; Cao, Yingui; Wu, Jainxue; Shahbazi, Mohammad Ali; Shi, Xiaoxiao; Reis, R. L.; Kundu, Subhas C; Xiao, BoThe therapeutic efficacy of oral nanotherapeutics against colorectal cancer (CRC) is restricted by inadequate drug accumulation, immunosuppressive microenvironment, and intestinal microbiota imbalance. To overcome these challenges, we elaborately constructed 6-gingerol (Gin)-loaded magnetic mesoporous silicon nanoparticles and functionalized their surface with mulberry leaf-extracted lipids (MLLs) and Pluronic ...
Dual-driven nanomotors enable tumour penetration and hypoxia alleviation for ca...
Wu, Jiaxue; Yi, Shixiong; Cao, Yingui; Zu, Menghang; Li, Baoyi; Yang, Wenjing; Shahbazi, Mohammad-Ali; Wan, Ying; Reis, R. L.; Kundu, Subhas CThe treatment efficacies of conventional medications against colorectal cancer (CRC) are restricted by a low penetrative, hypoxic, and immunosuppressive tumor microenvironment. To address these restrictions, we developed an innovative antitumor platform that employs calcium overload-phototherapy using mitochondrial N770-conjugated mesoporous silica nanoparticles loaded with CaO2 (CaO2–N770@MSNs). A loading leve...