7 documents found, page 1 of 1
Effect of two oral formulations of cannabidiol on responses to emotional stimul...
Crippa,José A.; Pereira Junior,Luiz C.; Pereira,Lívia C.; Zimmermann,Patrícia M.; Brum Junior,Liberato; Rechia,Letícia M.; Dias,IsabellaObjective: To compare plasma concentrations of cannabidiol (CBD) following oral administration of two formulations of the drug (powder and dissolved in oil), and to evaluate the effects of these distinct formulations on responses to emotional stimuli in healthy human volunteers. Methods: In a randomized, double-blind, placebo-controlled, parallel-group design, 45 healthy male volunteers were randomly assigned t...
Cannabidiol for the treatment of crack-cocaine craving: an exploratory double-b...
Meneses-Gaya,Carolina de; Crippa,José A.; Hallak,Jaime E.; Miguel,André Q.; Laranjeira,Ronaldo; Bressan,Rodrigo A.; Zuardi,Antonio W.; Lacerda,Acioly L.Objective: To assess the efficacy of cannabidiol (CBD) in the management of crack-cocaine craving and the treatment of frequent withdrawal symptoms. Methods: Thirty-one men with a diagnosis of crack-cocaine dependence were enrolled in a randomized, double-blind, placebo-controlled trial. We applied neuropsychological tests and assessed craving intensity, anxiety and depression symptoms, and substance use patter...
Increased body sway in phobic patients exposed to images of spiders
Linares,Ila M.P.; Nardi,Antonio E.; Guimarães,Francisco S.; Arrais,Katia C.; Chagas,Marcos H.; Osório,Flavia L.; Hallak,Jaime E.; Zuardi,Antonio W.Objective: The aim of the present study was to analyze the body sway response in specific phobia (SP) patients and healthy controls while viewing neutral, phobic, and disgusting images. Methods: The participants’ heart rate (HR) and skin conductance were also recorded during the procedure. Nineteen patients with arachnophobia and 19 healthy volunteers matched by age, gender, and years of education underwent a p...
Biological bases for a possible effect of cannabidiol in Parkinson’s disease
Ferreira-Junior,Nilson C.; Campos,Alline C.; Guimarães,Francisco S.; Del-Bel,Elaine; Zimmermann,Patrícia M. da R.; Brum Junior,Liberato; Hallak,Jaime E.Current pharmacotherapy of Parkinson’s disease (PD) is palliative and unable to modify the progression of neurodegeneration. Treatments that can improve patients’ quality of life with fewer side effects are needed, but not yet available. Cannabidiol (CBD), the major non-psychotomimetic constituent of cannabis, has received considerable research attention in the last decade. In this context, we aimed to critical...
Associations between primary health care strategies and outcomes of mental diso...
Moscovici,Leonardo; Balco,Estenifer M.; Degani,Natalia C.; Bolsoni,Lívia M.; Marques,João M.A.; Zuardi,Antonio W.Objective: To investigate associations between the percentage and severity of mental disorders (MD) and three different primary health care (PHC) strategies in Brazil: traditional care (TC), the Family Health Strategy (FHS), and FHS with shared mental health care (FHS+SC). Methods: Random samples were selected from three different areas of a Brazilian city. Each area was served by a different PHC strategy (TC, ...
Cannabidiol presents an inverted U-shaped dose-response curve in a simulated pu...
Linares,Ila M.; Zuardi,Antonio W.; Pereira,Luis C.; Queiroz,Regina H.; Mechoulam,Raphael; Guimarães,Francisco S.; Crippa,José A.Objective: Cannabidiol (CBD), one of the non-psychotomimetic compounds of Cannabis sativa, causes anxiolytic-like effects in animals, with typical bell-shaped dose-response curves. No study, however, has investigated whether increasing doses of this drug would also cause similar curves in humans. The objective of this study was to compare the acute effects of different doses of CBD and placebo in healthy volunt...
Acute and chronic administration of cannabidiol increases mitochondrial complex...
Valvassori,Samira S.; Bavaresco,Daniela V.; Scaini,Giselli; Varela,Roger B.; Streck,Emilio L.; Chagas,Marcos H.; Hallak,Jaime E.C.; Zuardi,Antonio W.Objective: To investigate the effects of cannabidiol (CBD) on mitochondrial complex and creatine kinase (CK) activity in the rat brain using spectrophotometry. Method: Male adult Wistar rats were given intraperitoneal injections of vehicle or CBD (15, 30, or 60 mg/kg) in an acute (single dose) or chronic (once daily for 14 consecutive days) regimen. The activities of mitochondrial complexes and CK were measured...