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Global age-sex-specific mortality, life expectancy, and population estimates in...

Schumacher, AE; Kyu, HH; Aali, A; Abbafati, C; Abbas, J; Abbasgholizadeh, R; Abbasi, MA; Abbasian, M; Abd ElHafeez, S; Abdelmasseh, M; Abd Elsalam, S

Background: Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 provides n...


MDR/XDR-TB management of patients and contacts: challenges facing the new decad...

Battista, Migliori, G; Tiberi, S; Zumla, A; Petersen, E; Muhwa Chakaya, J; Wejse, C; Muñoz Torrico, M; Duarte, R

The continuous flow of new research articles on MDR-TB diagnosis, treatment, prevention and rehabilitation requires frequent update of existing guidelines. This review is aimed at providing clinicians and public health staff with an updated and easy-to-consult document arising from consensus of Global Tuberculosis Network (GTN) experts. The core published documents and guidelines have been reviewed, including t...


New and repurposed drugs to treat multidrug- and extensively drug-resistant tub...

Silva, DR; Dalcolmo, M; Tiberi, S; Arbex, MA; Munoz-Torrico, M; Duarte, R; D'Ambrosio, L; Visca, D; Rendon, A; Gaga, M; Zumla, A; Migliori, GB

Multidrug-resistant and extensively drug-resistant tuberculosis (MDR-TB and XDR-TB, respectively) continue to represent a challenge for clinicians and public health authorities. Unfortunately, although there have been encouraging reports of higher success rates, the overall rate of favorable outcomes of M/XDR-TB treatment is only 54%, or much lower when the spectrum of drug resistance is beyond that of XDR-TB. ...



Agents of change: The role of healthcare workers in the prevention of nosocomia...

Nathavitharana, RR; Bond, P; Dramowski, A; Kotze, K; Lederer, P; Oxley, I; Peters, JA; Rossouw, C; van der Westhuizen, HM; Willems, B; Ting, TX

Healthcare workers (HCWs) play a central role in global tuberculosis (TB) elimination efforts but their contributions are undermined by occupational TB. HCWs have higher rates of latent and active TB than the general population due to persistent occupational TB exposure, particularly in settings where there is a high prevalence of undiagnosed TB in healthcare facilities and TB infection control (TB-IC) programm...


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