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Retinal drug delivery: rethinking outcomes for the efficient replication of ret...

Souto, Eliana B.; Sanchez-Lopez, Elena; Campos, Joana R.; da Ana, Raquel; Espina, Marta; Garcia, Maria L.; Severino, Patrí­cia; Batain, Fernando

The retina is a highly organized structure that is considered to be "an approachable part of the brain." It is attracting the interest of development scientists, as it provides a model neurovascular system. Over the last few years, we have been witnessing significant development in the knowledge of the mechanisms that induce the shape of the retinal vascular system, as well as knowledge of disease processes tha...


Spouted bed dried Rosmarinus officinalis extract: a novel approach for physicoc...

Souza, Claudia R. F.; Baldim, Iara; Bankole, Victor O.; da Ana, Raquel; Durazzo, Alessandra; Lucarini, Massimo; Cicero, Nicola; Santini, Antonello

In this study, a conical-cylindrical spouted bed dryer with Teflon® beads as spouting material was used for producing powdered rosemary (Rosmarinus officinalis L.) extract. The influence of the inlet drying gas temperature (Tgi) and the percentage ratio between the feed rate of concentrated liquid extract by the maximum evaporation capacity of the spouted bed (Ws/Wmax) on selected physicochemical properties of ...


In vitro characterization, modelling, and antioxidant properties of Polyphenon-...

Souto, Eliana B.; da Ana, Raquel; Souto, Selma B.; Zielinska, Aleksandra; Marques, Conrado; Andrade, Luciana N.; Horbanczuk, Olaf K.

Eudragit S100-coated chitosan microspheres (S100Ch) are proposed as a new oral delivery system for green tea polyphenon-60 (PP60). PP60 is a mixture of polyphenolic compounds, known for its active role in decreasing oxidative stress and metabolic risk factors involved in diabetes and in other chronic diseases. Chitosan-PP60 microspheres prepared by an emulsion cross-linking method were coated with Eudragit S100...


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