4 documents found, page 1 of 1
Transjugular liver biopsy: the key to a rare etiology of cholestatic hepatitis ...
Pestana, Inês; Pedro, Juliana; Simões, Carolina; Ferreira, Carlos; da Mata, Sara; Claro, IsabelIntroduction: Hematopoietic stem cell transplantation (HSCT) is associated with multiple complications, such as sinusoidal obstruction syndrome (SOS) (hepatomegaly, ascites, jaundice, and thrombocytopenia) and graft-versus-host disease (GVHD) (with the skin, gastrointestinal tract, and liver being the main targets). These entities may present overlapping clinical findings, being considered differential diagnose...
Digital pathology implementation in a private laboratory: The CEDAP experience
Ferreira, Inês; Montenegro, Carlos Sachica; Coelho, Daniel; Pereira, Maria; da Mata, Sara; Carvalho, Sofia; Araújo, Ana Catarina; Abrantes, CarlosIntroduction: The transition to digital pathology has been carried out by several laboratories across the globe, with some cases described in Portugal. In this article,we describe the transition to digital pathology in a high-volume private laboratory, considering the main challenges and opportunities. Material and methods: Our process started in 2020, with laboratory workflow adaptation and we are currently us...
Patient-derived explants of colorectal cancer: histopathological and molecular ...
da Mata, Sara; Franchi-Mendes, Teresa; Abreu, Sofia; Filipe, Bruno; Morgado, Sónia; Mesquita, Marta; Albuquerque, Cristina; Fonseca, RicardoColorectal cancer (CRC) is one of the most common cancers worldwide. Although short-term cultures of tumour sections and xenotransplants have been used to determine drug efficacy, the results frequently fail to confer clinically useful information. Biomarker discovery has changed the paradigm for advanced CRC, though the presence of a biomarker does not necessarily translate into therapeutic success. To improve...
Methylation patterns in dysplasia in inflammatory bowel disease patients
Rosa, Isadora; Silva, Patricia; da Mata, Sara; Magro, Fernando; Carneiro, Fatima; Peixoto, Armando; Silva, Marco; Sousa, Helena Tavares; Roseira, JoanaBackground and aims:Inflammatory Bowel Disease (IBD) with colonic involvement increases colorectal cancer risk. However, the distinction between IBD related and sporadic dysplasia in IBD patients is difficult. Some data favors the importance of abnormal DNA methylation in IBD-related carcinogenesis. We aimed to define methylation patterns in patients with colonic cancer or dysplasia diagnosis following an IBD d...