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SYNTHESIS, LARVICIDAL AND ACETYLCHOLINESTERASE INHIBITORY ACTIVITIES OF CARVACR...
Mesquita,Bruna M. de; Nascimento,Patricia G. G. do; Souza,Luciana G. S.; Farias,Iolanda F. de; Silva,Romézio A. C. da; Lemos,Telma L. G. deIn order to produce bioactive derivatives of carvacrol and thymol, nine derivatives of each compound were prepared through modifications the phenolic hydroxyl group. The structures of compounds were confirmed by spectral data from MS, IR and NMR. Carvacrol, thymol and derivatives were submitted to the evaluation of the inhibition of the enzyme acetylcholinesterase, using a colorimetric method in which the inhib...
Withanolides from Leaves of Nicandra physalodes
Carrero,Diego A. S.; Batista,Pedro H. J.; Souza,Luciana G. S.; Pinto,Francisco C. L.; Vasconcelos,Mayron A. de; Teixeira,Edson H.; Canuto,Kirley M.Five new withanolides, designated as 15-oxo-nicaphysalin B, 6β,7α-dihydroxynicandrenone 10, 24α,25β-dihydroxy-nicandrenone-2 and a mixture of the epimers 17-(1α/1β-methylpropanone)-nicandrenone, in addition to six known others, were isolated from the leaf acetone extract from Nicandra physalodes. The complete structures of the five new withanolides, particularly their relative stereochemistries, were establishe...
Brazoides A-D, New Alkaloids from Justicia gendarussa Burm. F. Species
Souza,Luciana G. S.; Almeida,Macia C. S.; Lemos,Telma L. G.; Ribeiro,Paulo R. V.; Canuto,Kirley M.; Braz-Filho,Raimundo; Cistia,Catarina N. DelFour new alkaloids, Brazoides A-D, together with three known compounds squalene, β-sitosterol and lupeol, were isolated from leaves of Justicia gendarussa. These structures were established by spectrometric techniques, mainly high-resolution electrospray ionization mass spectrometry (HRESIMS) and 1D and 2D nuclear magnetic resonance (NMR), including comparative analysis with literature values. Structural determ...
New Epimeric Spirostanol and Furostanol-Type Steroidal Saponins from Cestrum la...
Ribeiro,Paulo R. V.; Braz-Filho,Raimundo; Araújo,Ana J.; Costa-Lotufo,Letícia V.; Souza,Luciana G. S.; Nobre Junior,Hélio V.; Silva,Cecília R. daFour new epimeric spirostanol and furostanol-type steroidal saponins, (25R,S)-5α-spirostan-2α,3β-diol 3-O-β-D-glucopyranosyl-(1→4)-β-D-galactopyranosyl-(1→4)-β-D-galactopyranoside, (25R,S)-5α-spirostan-2α,3β-diol 3-O-β-D-glucopyranosyl-(1→2)-α-L-rhamnopyranosyl-(1→4)-β-D-galactopyranoside, 26-O-β-D-glucopyranosyl-(25R,S)-5α-furost-20-ene,2α,3β-diol 3-O-β-D-galactopyranoside and 26-O-β-D-glucopyranosyl-(25R,S)-5...