3 documents found, page 1 of 1
Intrabodies targeting the Kaposi sarcoma-associated herpesvirus latency antigen...
Corte-Real, S; Collins, C; da Silva, FA; Simas, JP; Barbas, CF; Chang, Y; Moore, P; Goncalves, JKaposi sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen-1 (LANA1) is essential for the maintenance and segregation of viral episomes in KSHV latently infected B cells. We report development of intracellular, rabbit-derived antibodi
HIV-1 Vif can directly inhibit apolipoprotein B mRNA-editing enzyme catalytic p...
Santa-Marta, M; da Silva, FA; Fonseca, AM; Goncalves, JThe human apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G (APOBEC3G), also known as CEM-15, is a host-cell factor involved in innate resistance to retroviral infection. HIV-1 viral infectivity factor (Vif) protein was shown to protect t
Camelized rabbit-derived VH single-domain Intrabodies Against vif strongly neut...
da Silva, FA; Santa-Marta, M; Freitas-Vieira, A; Mascarenhas, P; Barahona, I; Moniz-Pereira, J; Gabuzda, D; Goncalves, JWe recently developed a specific single-chain antibody from immunized rabbits to HIV-1 Vif protein that was expressed intracellularly and inhibited reverse transcription and viral replication. The Vif of HIV-1 overcomes the innate antiviral activity of a