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3D bioprinting of gellan gum-based hydrogels tethered with laminin-derived pept...

Alheib, Omar; da Silva, Lucília P.; Youn, Yun Hee; Kwon, Il Keun; Reis, R. L.; Correlo, V. M.

The treatment of skeletal muscle defects is still a topic of noteworthy concern since surgical intervention is not capable of recovering muscle function. Herein, we propose myoblasts laden in laminin-inspired biofunctionalized gellan gum hydrogels as promising tissue-engineered skeletal muscle surrogates. Gellan gum-based hydrogels were developed by combining native gellan gum (GG) and GG tethered with laminin-...


Micropatterned silk-fibroin/eumelanin composite films for bioelectronic applica...

Youn, Yun Hee; Pradhan, Sayantan; da Silva, Lucília P.; Kwon, Il Keun; Kundu, Subhas C; Reis, R. L.; Yadavalli, Vamsi K.; Correlo, V. M.

There has been growing interest in the use of natural bionanomaterials and nanostructured systems for diverse biomedical applications. Such materials can confer unique functional properties as well as address concerns pertaining to sustainability in production. In this work, we propose the biofabrication of micropatterned silk fibroin/eumelanin composite thin films to be used in electroactive and bioactive appl...


Convection patterns gradients of non-living and living micro-entities in hydrogels

Canadas, Raphael Faustino; Patrício, Pedro; Brancato, Virginia; Gasperini, Luca; Caballero, David; Pires, Ricardo A; Costa, João B.; Pereira, Hélder

Inducing thermal gradients in two injected fluid systems results in the temporal formation of mixing conductive streams. If preserved through sol-gel transition, this mechanism can be used to drive and pattern non-living and living entities in mixed hydrogels. Interfaces are vital in nature, where gradients of non-living and living entities build distinct yet continuous integrated living tissues. However, the c...


Convection patterns gradients of non-living and living micro-entities in hydrogels

Canadas, Raphaël F.; Patricio, Pedro; Brancato, Virginia; Gasperini, Luca; Caballero, David; Pires, Ricardo A.; Costa, João; Pereira, Hélder; Yong, Ping

Inducing thermal gradients in two injected fluid systems results in the temporal formation of mixing conductive streams. If preserved through sol-gel transition, this mechanism can be used to drive and pattern non-living and living entities in mixed hydrogels. Interfaces are vital in nature, where gradients of non-living and living entities build distinct yet continuous integrated living tissues. However, the c...


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