Made available in DSpace on 2021-06-25T11:18:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-05-11; The way in which transcriptional activity overcomes the physical DNA structure and gene regulation mechanisms involves complex processes that are not yet fully understood. Modifications in the cytosine-guanine sequence of DNA by 5-mC are preferentially located in heterochromatic regions and are related ...