3 documents found, page 1 of 1
Mechanisms of Resistance to BCR-ABL Kinase Inhibitors
Diamond, Joana; da Silva, Maria GomesSince the introduction of imatinib mesylate for the treatment of chronic myeloid leukaemia, impressive clinical responses were observed in the majority of patients in chronic phase. However, not all patients experience an optimal response to imatinib mesylate or even to the more potent, second generation tyrosine kinase inhibitors. Furthermore, responses are not sustained in a number of patients, and it is yet ...
Three-way translocation (X;20;16)(p11;q13;q23) in essential thrombocythemia imp...
Vieira, Luís; Vaz, Andreia; Matos, Paulo; Ambrósio, Ana Paula; Nogueira, Manel; Marques, Bárbara; Pereira, AM; Jordan, Peter; da Silva, Maria GomesEssential thrombocythemia (ET) is a myeloproliferative neoplasm essentially characterized by excessive production of platelets. Molecular pathogenesis of ET is linked in approximately half of the patients to intracellular cytokine signaling dysregulation as a result of thrombopoietin receptor or Janus kinase 2 (JAK2) mutations. However, genetic defects underlying cytokine transcription have not been associated ...
Differentiation of human peripheral blood Vδ1+ T cells expressing the natural c...
Correia, Daniel V.; Fogli, Manuela; Hudspeth, Kelly; da Silva, Maria Gomes; Mavilio, Domenico; Silva-Santos, BrunoThe success of cancer immunotherapy depends on productive tumor cell recognition by killer lymphocytes. γδ T cells are a population of innate-like lymphocytes endowed with strong, MHC-unrestricted cytotoxicity against tumor cells. This notwithstanding, we recently showed that a large proportion of human hematologic tumors is resistant to γδ peripheral blood lymphocytes (PBLs) activated with specific agonists to...