Encontrados 21 documentos, a visualizar página 1 de 3
Polymorphisms in Genes of Lipid Metabolism Are Associated with Type 2 Diabetes ...
Nicchio, Ingra G. [UNESP]; Cirelli, Thamiris [UNESP]; Nepomuceno, Rafael [UNESP]; Hidalgo, Marco A.R. [UNESP]; Rossa, Carlos [UNESP]Made available in DSpace on 2022-04-29T08:36:50Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01; Background. Type 2 diabetes mellitus (T2DM) and periodontitis (P) commonly occur as comorbidities, but the commonalities in the genetic makeup of affected individuals is largely unknown. Since dyslipidemia is a frequent condition in these individuals, we investigate the association of genomic variations...
Galanin mediates tumor-induced immunosuppression in head and neck squamous cell...
de Medeiros, Marcell Costa; Liu, Min; Banerjee, Rajat; Bellile, Emily; D’Silva, Nisha J.; Rossa, Carlos [UNESP]Made available in DSpace on 2022-04-29T08:40:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-01-01; Purpose: Galanin receptor 2 (GALR2) plays a significant role in the progression of head and neck squamous cell carcinomas (HNSCC). Since there is virtually no information on immunomodulation mediated by its ligand in the tumor microenvironment, we assessed the effects of galanin on peripheral blood mono...
Periodontal Disease and Inflammation-Induced Bone Remodeling
Graves, Dana T.; Rosenstein, Elliot D.; Rossa, Carlos [UNESP]; Fiorellini, Joseph P.Made available in DSpace on 2022-04-29T07:12:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-04-05; Department of Periodontics University of Pennsylvania School of Dental Medicine; Division of Clinical Immunology Mount Sinai School of Medicine; Institute of Rheumatic and Autoimmune Diseases Overlook Medical Center Summit; Department of Diagnosis and Surgery School of Dentistry at Araraquara-State Univ...
Validation in a Brazilian population of gene markers of periodontitis previousl...
Cirelli, Thamiris [UNESP]; Nepomuceno, Rafael [UNESP]; Orrico, Silvana R. P. [UNESP]; Rossa, Carlos [UNESP]; Cirelli, Joni A. [UNESP]; North, Kari E.Made available in DSpace on 2021-06-25T10:34:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-05-01; Background: Bioinformatic tools and genome-wide association studies (GWAS) have led to comprehensive identification of single nucleotide polymorphisms (SNPs) associated with periodontitis in diverse populations. Here we aimed to detect and validate the association of seven SNPs as genetic markers of sus...
Local application of curcumin-loaded nanoparticles as an adjunct to scaling and...
Pérez-Pacheco, Cindy Grace [UNESP]; Fernandes, Natalie Ap. Rodrigues [UNESP]; Primo, Fernando Lucas [UNESP]; Tedesco, Antonio Claudio; Bellile, EmilyMade available in DSpace on 2021-06-25T10:37:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-05-01; Objective: Assess a single local application of curcumin-loaded nanoparticles as an adjunct to scaling and root planing (SRP) in nonsurgical periodontal treatment (NPT). Materials and methods: Twenty healthy subjects with periodontitis received SRP+PLGA/PLA nanoparticles loaded with 50 μg of curcumin (N...
Silencing matrix metalloproteinase-13 (Mmp-13) reduces inflammatory bone resorp...
Guimaraes-Stabili, Morgana R. [UNESP]; de Medeiros, Marcell Costa [UNESP]; Rossi, Danuza [UNESP]; Camilli, Angelo Constantino [UNESP]Made available in DSpace on 2021-06-25T10:37:51Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-05-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Objectives: The aim of this study was to evaluate the effect of specific inhibition of MMP-13 on inflammation and inflammatory bone resorption in a murine model of lipopolysaccharide (LPS)-induced periodontitis. Materials and methods: Period...
Smoking reduces cathelicidin LL-37 and human neutrophil peptide 1–3 levels in t...
Soldati, Kahena R. [UNESP]; Toledo, Felipe A. [UNESP]; Aquino, Sabrina G.; Rossa, Carlos [UNESP]; Deng, Dongmei; Zandim-Barcelos, Daniela L. [UNESP]Made available in DSpace on 2020-12-12T02:20:59Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01; Background: Antimicrobial peptides are components of innate immune response that have a key role on susceptibility and resistance of the oral cavity to diseases. This study aimed to investigate the influence of smoking on cathelicidin LL-37 and human neutrophil peptides 1 through 3 (HNP 1‒3) levels in t...
Severe magnesium deficiency compromises systemic bone mineral density and aggra...
Belluci, Marina Montosa [UNESP]; de Molon, Rafael Scaf [UNESP]; Rossa, Carlos [UNESP]; Tetradis, Sotirios; Giro, Gabriela; Cerri, Paulo Sergio [UNESP]Made available in DSpace on 2020-12-12T01:48:46Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-03-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); We sought to evaluate the effects of magnesium (Mg) intake deficiency on bone metabolism in rats with induced periodontal disease (PD). Holtzman rats were randomly divided ...
NLRC4 inflammasome has a protective role on inflammatory bone resorption in a m...
Rocha, Fernanda R.G. [UNESP]; Delitto, Andrea E.; de Souza, Joao A Chaves; Maldonado, Laura A.G. [UNESP]; Wallet, Shannon M.; Rossa, Carlos [UNESP]Made available in DSpace on 2020-12-12T01:50:04Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01; There is virtually no information on the role of NLRC4 inflammasome on bone resorption and inflammation associated with periodontitis. Bacterial-associated experimental periodontitis was induced in wild-type (WT) and Nlrc4-KO C57BL/6 mice. 3 μL of a 1 × 109 UFC/mL PBS suspension of heat-killed Gram-nega...
Systemic administration of curcumin or piperine enhances the periodontal repair...
Guimaraes-Stabili, Morgana R. [UNESP]; de Aquino, Sabrina Garcia; de Almeida Curylofo, Fabiana [UNESP]; Tasso, Camilla Olga [UNESP]Made available in DSpace on 2019-10-06T16:07:58Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-08-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Objectives: Studies have documented the anti-inflammatory effects of spices, which may be related to treatment of chronic diseases. The purpose of this study was to evaluate the influence of curcumin and piperine and their association on exp...