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Lipid nanocarriers for anti-HIV therapeutics: a focus on physicochemical proper...
Faria, Maria João; Lopes, Carla Martins; das Neves, José; Lúcio, MarleneSince HIV was first identified, and in a relatively short period of time, AIDS has become one of the most devastating infectious diseases of the 21st century. Classical antiretroviral therapies were a major step forward in disease treatment options, significantly improving the survival rates of HIV-infected individuals. Even though these therapies have greatly improved HIV clinical outcomes, antiretrovirals (AR...
Polymeric electrospun fibrous dressings for topical co-delivery of acyclovir an...
Costa, Tiago; Ribeiro, Artur; Machado, Raul; Ribeiro, Clarisse; Lanceros-Méndez, S.; Cavaco-Paulo, Artur; Almeida, Andreia; das Neves, José; Lúcio, M.Herpetic infections caused by Herpes simplex virus (HSV) are among the most common human infections, affecting more than two quarters of the world's population. The standard treatment for orofacial herpes is the administration of antiviral drugs, mainly acyclovir (ACV). However, current products are mostly based on semisolid formulations that have limited ability to promote drug skin penetration and tend to lea...
Rational development of liposomal hydrogels: A strategy for topical vaginal ant...
Faria, Maria J.; Machado, Raul; Ribeiro, Artur; Gonçalves, Hugo; Real Oliveira, M. Elisabete C.D.; Viseu, T. M. R.; das Neves, José; Lúcio, M.HIV/AIDS stands as a global burden, and vaginal microbicides constitute a promising strategy for topical pre-exposure prophylaxis. Preceding the development of a microbicide containing tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC), in silico and in vitro studies were performed to evaluate the physicochemical characteristics of both drugs, and to study their biophysical impact in lipid model system...
Measuring progress and projecting attainment on the basis of past trends of the...
Fullman, Nancy; Barber, Ryan M; Abajobir, Amanuel Alemu; Abate, Kalkidan Hassen; Abbafati, Cristiana; Abbas, Kaja M; Abd-Allah, FoadBackground: The UN's Sustainable Development Goals (SDGs) are grounded in the global ambition of "leaving no one behind". Understanding today's gains and gaps for the health-related SDGs is essential for decision makers as they aim to improve the health of populations. As part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016), we measured 37 of the 50 health-related SDG indicato...