2 documents found, page 1 of 1
Association Between Iron-Related Protein Lipocalin 2 and Cognitive Impairment i...
das Neves, Sofia Pereira; Taipa, Ricardo; Marques, Fernanda; Soares Costa, Patrício; Monárrez-Espino, Joel; Palha, Joana A.; Kivipelto, MiiaA worldwide increase in longevity is bringing novel challenges to public health and health care professionals. Cognitive impairment in the elderly may compromise living conditions and precede Alzheimer's disease (AD), the most prevalent form of dementia. Therefore, finding molecular markers associated with cognitive impairment is of crucial importance. Lipocalin 2 (LCN2), an iron-related protein, has been sugge...
Structural and molecular correlates of cognitive aging in the rat
Mota, Cristina; Taipa, Ricardo; das Neves, Sofia Pereira; Monteiro-Martins, Sara; Monteiro, Susana; Palha, Joana Almeida; Sousa, NunoAging is associated with cognitive decline. Herein, we studied a large cohort of old age and young adult male rats and confirmed that, as a group, old rats display poorer spatial learning and behavioral flexibility than younger adults. Surprisingly, when animals were clustered as good and bad performers, our data revealed that while in younger animals better cognitive performance was associated with longer den...