2 documents found, page 1 of 1
The Aspergillus fumigatus Mismatch Repair MSH2 Homolog Is Important for Virulen...
Dos Reis, Thaila Fernanda; Silva, Lilian Pereira; de Castro, Patrícia Alves; do Carmo, Rafaela Andrade; Marini, Marjorie MendesThe genetic stability of every living organism depends on accurate DNA replication and repair systems. Here, we investigated the Aspergillus fumigatusMSH2 mismatch repair (MMR) gene MshA and how it impacts virulence and the evolution of azole resistance. We examined mshA gene variation in 62 environmental and clinical A. fumigatus strains. We have observed 12 strains with variants (18.2%), and 8 strains among t...
The Aspergillus fumigatus CrzA Transcription Factor Activates Chitin Synthase G...
Ries, Laure Nicolas Annick; Rocha, Marina Campos; de Castro, Patrícia Alves; Silva-Rocha, Rafael; Silva, Roberto Nascimento; Freitas, Fernanda ZanolliMade available in DSpace on 2018-12-11T16:49:34Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-06-13; Aspergillus fumigatus is an opportunistic fungal pathogen that causes invasive aspergillosis (IA), a life-threatening disease in immunocompromised humans. The echinocandin caspofungin, adopted as a second-line therapy in combating IA, is a β-1,3-glucan synthase inhibitor, which, when used in high concen...