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Maternal longevity is associated with reduced risk but an earlier onset of alzh...
Tábuas-Pereira, Miguel; Mano, Francisco; Bernardes, Catarina; Durães, João; Lima, Marisa; DenHaan, Kaitlyn; Paquette, Kimberly; Kun-Rodrigues, CéliaWhile human longevity has increased significantly over the last 2 centuries, the time spent in good physical and cognitive health has not risen proportionately. The incidence of Alzheimer’s disease (AD) increases with age, but parental longevity is often associated with better offspring health and lower AD risk. This study aimed to investigate the relationship between parental longevity and AD. We included pati...
Communication in Neonatal Intensive Care: Translation and Validation of the “Pa...
Melo Parente, Rita; Guerreiro, Rita; Garcia, Laura; Sanches, Bruno; Gomes, Raquel; Rocha, Maria Clara; Costa, AnselmoIntroduction: Communication is a fundamental aspect in healthcare, more so in fragile environments such as Neonatology. To optimize communication strategies with parents, it is essential to assess its quality. The aim of this study was to validate, for the Portuguese population, an instrument for assessing the quality of communication between healthcare professionals and parents in neonatal care units. Methods:...
Exploring first-degree family history in a cohort of Portuguese Alzheimer’s dis...
Tábuas-Pereira, Miguel; Bernardes, Catarina; Durães, João; Lima, Marisa; Nogueira, Ana Rita; Saraiva, Jorge; Tábuas, Teresa; Coelho, MarianaAlzheimer’s disease (AD) heritability is estimated to be around 70–80%. Yet, much of it remains to be explained. Studying transmission patterns may help in understanding other factors contributing to the development of AD. In this study, we aimed to search for evidence of autosomal recessive or X- and Y-linked inheritance of risk factors in a large cohort of Portuguese AD patients. We collected family history f...
The Cost of Meningococcal Meningitis in Portugal
Rodrigues, Fernanda; Pinheiro, Bernardete; Guerreiro, Rita; Gouveia, Miguel; Eloi, João; Alves, Cristina; Castela, Guilherme; Oliveira, AlexandraIntroduction: Invasive meningococcal disease (IMD) is an infection caused by the bacterium Neisseria meningitidis, and a major cause of meningitis (MM) and/or septicemia (MS). The aim of this study is to estimate the costs of IMD (MM and MS) for Portuguese state.Methods: To estimate the costs associated with IMD, a model was developed, where patients can have one of three outcomes: survive without sequelae, sur...
Reconsidering the role of blood-brain barrier in Alzheimer's disease: From deli...
Sousa, João André; Bernardes, Catarina; Bernardo-Castro, Sara; Lino, Miguel; Albino, Inês; Ferreira, Lino; Brás, José; Guerreiro, RitaThe existence of a selective blood-brain barrier (BBB) and neurovascular coupling are two unique central nervous system vasculature features that result in an intimate relationship between neurons, glia, and blood vessels. This leads to a significant pathophysiological overlap between neurodegenerative and cerebrovascular diseases. Alzheimer's disease (AD) is the most prevalent neurodegenerative disease whose p...
Bat algorithm for discrete optimization problems: an analysis
Sousa, Bruno; Guerreiro, Rita; Santos, André S.; Bastos, João A.; Varela, M.L.R.; Brito, Marlene F.In this article the application of the discrete version of the bat algorithm to flowshop scheduling problems is presented and compared with Simulated Annealing, Local Search, as well as versions of each that start from constructive heuristics (Palmer and CDS). Bat algorithm is a novel metaheuristic, developed for continuous problems that has shown exceptional results. This paper intends to assess its effectiven...
Online scheduling: a survey
Guerreiro, Rita; Santos, Andre S.; Tereso, Anabela PereiraIn this article a deep search of the literature of online scheduling is conducted. This paper intends to assess the developments and solutions found for online scheduling problems. Online scheduling is a very important topic since most of the real scheduling problems have dynamic characteristics. First, it was developed a literature review about scheduling problems, dividing them in stochastic and deterministic...
Altered plasma protein profiles in genetic FTD – a GENFI study
Ullgren, Abbe; Öijerstedt, Linn; Olofsson, Jennie; Bergström, Sofia; Remnestål, Julia; van Swieten, John C.; Jiskoot, Lize C.; Seelaar, HarroBackground: Plasma biomarkers reflecting the pathology of frontotemporal dementia would add significant value to clinical practice, to the design and implementation of treatment trials as well as our understanding of disease mechanisms. The aim of this study was to explore the levels of multiple plasma proteins in individuals from families with genetic frontotemporal dementia. Methods: Blood samples from 693 pa...
Examining empathy deficits across familial forms of frontotemporal dementia wit...
Foster, Phoebe H.; Russell, Lucy L.; Peakman, Georgia; Convery, Rhian S.; Bouzigues, Arabella; Greaves, Caroline V.; Bocchetta, Martina; Cash, David M.Background: Reduced empathy is a common symptom in frontotemporal dementia (FTD). Although empathy deficits have been extensively researched in sporadic cases, few studies have explored the differences in familial forms of FTD. Methods: Empathy was examined using a modified version of the Interpersonal Reactivity Index (mIRI) in 676 participants from the Genetic FTD Initiative: 216 mutation-negative controls, 1...
A data-driven disease progression model of fluid biomarkers in genetic frontote...
van der Ende, Emma L.; Bron, Esther E.; Poos, Jackie M.; Jiskoot, Lize C.; Panman, Jessica L.; Papma, Janne M.; Meeter, Lieke H.; Dopper, Elise G. P.Several CSF and blood biomarkers for genetic frontotemporal dementia have been proposed, including those reflecting neuroaxonal loss (neurofilament light chain and phosphorylated neurofilament heavy chain), synapse dysfunction [neuronal pentraxin 2 (NPTX2)], astrogliosis (glial fibrillary acidic protein) and complement activation (C1q, C3b). Determining the sequence in which biomarkers become abnormal over the ...