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Overexpression of wild-type IL-7Rα promotes T-cell acute lymphoblastic leukemia...

Silva, Ana Teresa; Almeida, Afonso R. M.; Cachucho, Ana; Neto, João L.; Demeyer, Sofie; de Matos, Mafalda; Hogan, Thea; Li, Yunlei; Meijerink, Jules

U117573801 MR/P011225/1 ERC CoG-648455 KiKa 2010-082; Tight regulation of IL-7Rα expression is essential for normal T-cell development. IL-7Rα gain-of-function mutations are known drivers of T-cell acute lymphoblastic leukemia (T-ALL). Although a subset of patients with T-ALL display high IL7R messenger RNA levels and cases with IL7R gains have been reported, the impact of IL-7Rα overexpression, rather than mut...

Date: 2021   |   Origin: Repositório Institucional da UNL
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