12 documents found, page 1 of 2
Injectable and implantable hydrogels for localized delivery of drugs and nanoma...
Pouso, Manuel António do Rosário; Melo, Bruna Daniela Lopes; Gonçalves, Joaquim; Louro, Ricardo; Mendonça, António; Correia, Ilídio Joaquim SobreiraMultiple chemotherapeutic strategies have been developed to tackle the complexity of cancer. Still, the outcome of chemotherapeutic regimens remains impaired by the drugs’ weak solubility, unspecific biodistribution and poor tumor accumulation after systemic administration. Such constraints triggered the development of nanomaterials to encapsulate and deliver anticancer drugs. In fact, the loading of drugs into...
Dual-crosslinked injectable in situ forming Alginate/CaCl2/Pluronic F127/ α-Cyc...
Gonçalves, Joaquim; Melo, Bruna Daniela Lopes; Pouso, Manuel António do Rosário; Correia, Ilídio Joaquim Sobreira; de Melo-Diogo, DuarteInjectable in situ forming hydrogels have been emerging due to their capacity to perform the direct delivery of therapeutics into the tumor site with minimal off-target leakage. Particularly, physical crosslinked injectable in situ forming hydrogels are appealing due to their straightforward preparation that exploits the native jointing capabilities of specific polymers/materials. However, the features of these...
UV-crosslinked biomaterials: Functionalized polyethylene glycol for tissue adhe...
Cernadas, Maria Teresa; Ferreira, Mariana; Melo, Bruna Daniela Lopes; de Melo-Diogo, Duarte; Correia, Ilídio Joaquim SobreiraSurgeons around the world face the challenge of effectively and securely treat acute wounds. The most used techniques used to reestablish proper tissue continuity and promote healing comprise surgical tape strips and wound suturing or stapling. However, these have different limitations associated, like additional tissue trauma and patient discomfort. Tissue adhesives have emerged as a promising alternative to t...
Renewable Photo-Cross-Linkable Polyester-Based Biomaterials: Synthesis, Charact...
Cernadas, Maria Teresa; Pereira, João; Melo, Bruna Daniela Lopes; de Melo-Diogo, Duarte; Correia, Ilídio Joaquim Sobreira; Alves, PatríciaTThe present work consist of the synthesis of photo-crosslinkable materials, based on unsaturated polyesters (UPs), synthesized from biobased monomers from renewable sources such as itaconic acid and 1,4- butanediol. The UPs were characterized to assess the influence of polycondensation reaction temperature and cross-linking time on their final properties. For this purpose, different UV irradiation exposure per...
Poly(2-ethyl-2-oxazoline)–IR780 conjugate nanoparticles for breast cancer photo...
Alves, Cátia; Lima-Sousa, Rita; Melo, Bruna L.; Ferreira, Paula; Moreira, André; Correia, I.J.; de Melo-Diogo, DuarteConventional anticancer approaches are often associated with severe side effects. Herein, the authors assembled a novel nanoparticle whose therapeutic effect is triggered by laser light. In in vitro assays, the produced nanomaterial was able to, after interacting with laser light, reduce the viability of classic and advanced cancer models. In these conditions, but in the absence of laser light, no cytotoxicity ...
Sulfobetaine methacrylate-coated reduced graphene oxide-IR780 hybrid nanosystem...
Melo, Bruna L.; Lima-Sousa, Rita; Alves, Cátia; Correia, I.J.; de Melo-Diogo, DuarteNanomaterials with near infrared light absorption can mediate an antitumoral photothermal-photodynamic response that is weakly affected by cancer cells’ resistance mechanisms. Such nanosystems are commonly prepared by loading photosensitizers into nanomaterials displaying photothermal capacity, followed by functionalization to achieve biological compatibility. However, the translation of these multifunctional n...
Injectable hydrogels for the delivery of nanomaterials for cancer combinatorial...
Lima-Sousa, Rita; Alves, Cátia; Melo, Bruna L.; Costa, Francisco J. P.; Nave, Micaela; Moreira, André F.; Mendonça, António; Correia, I.J.Progress in the nanotechnology field has led to the development of a new class of materials capable of producing a temperature increase triggered by near infrared light. These photothermal nanostructures have been extensively explored in the ablation of cancer cells. Nevertheless, the available data in the literature have exposed that systemically administered nanomaterials have a poor tumor-homing capacity, hi...
Multifunctional targeted solid lipid nanoparticles for combined photothermal th...
Granja, Andreia; Lima-Sousa, Rita; Alves, Cátia; de Melo-Diogo, Duarte; Nunes, Cláudia; Sousa, Célia T.; Correia, I.J.; Reis, SalettePhotothermal therapy has emerged as a new promising strategy for the management of cancer, either alone or combined with other therapeutics, such as chemotherapy. The use of nanoparticles for multimodal therapy can improve treatment performance and reduce drug doses and associated side effects. Here we propose the development of a novel multifunctional nanosystem based on solid lipid nanoparticles co-loaded wit...
Optimization of the GSH-Mediated Formation of Mesoporous Silica-Coated Gold Nan...
Fernandes, Natanael; Rodrigues, Carolina F; de Melo-Diogo, Duarte; Correia, Ilídio J.; Moreira, André FCancer light-triggered hyperthermia mediated by nanomaterials aims to eliminate cancer cells by inducing localized temperature increases to values superior to 42 °C, upon irradiation with a laser. Among the different nanomaterials with photothermal capacity, the gold-based nanoparticles have been widely studied due to their structural plasticity and advantageous physicochemical properties. Herein, a novel and s...
Electrospun Asymmetric Membranes as Promising Wound Dressings: A Review
Graça, Mariana F. P.; de Melo-Diogo, Duarte; Correia, Ilídio J.; Moreira, André F.Despite all the efforts that have been done up to now, the currently available wound dressings are still unable to fully re-establish all the structural and functional properties of the native skin. To overcome this situation, researchers from the tissue engineering area have been developing new wound dressings (hydrogels, films, sponges, membranes) aiming to mimic all the features of native skin. Among them, a...