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Genome-Wide Analysis of PAPS1-Dependent Polyadenylation Identifies Novel Roles ...
Kappel, Christian; Trost, Gerda; Czesnick, Hjördis; Ramming, Anna; Kolbe, Benjamin; Vi, Son Lang; Bispo, Cláudia; Becker, Jörg D.; de Moor, CorneliaThe poly(A) tail at 3' ends of eukaryotic mRNAs promotes their nuclear export, stability and translational efficiency, and changes in its length can strongly impact gene expression. The Arabidopsis thaliana genome encodes three canonical nuclear poly(A) polymerases, PAPS1, PAPS2 and PAPS4. As shown by their different mutant phenotypes, these three isoforms are functionally specialized, with PAPS1 modifying orga...
Date: 2015
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Origin: ARCA - Access to Research and Communication Annals