2 documents found, page 1 of 1
Effects of serine or threonine in the active site of typical 2-cys prx on hyper...
Tairum, Carlos A. [UNESP]; Santos, Melina Cardoso [UNESP]; Breyer, Carlos Alexandre [UNESP]; de Oliveira, Ana Laura Pires [UNESP]Made available in DSpace on 2022-05-01T05:29:33Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-07-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Typical 2-Cys peroxiredoxins (2-Cys Prx) are ubiquitous Cys-based peroxidases, which are stable as decamers in the reduced state, and may dissociate into dimers upon disulfide bond formation. A peroxidatic Cys (CP) takes part of a catalytic ...
Functional and structural evaluation of the antileukaemic enzyme l-asparaginase...
de Moura, Werner Alfinito Feio [UNESP]; Schultz, Leonardo [UNESP]; Breyer, Carlos Alexandre [UNESP]; de Oliveira, Ana Laura Pires [UNESP]Made available in DSpace on 2020-12-12T02:45:48Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01; Acute lymphoblastic leukaemia (ALL) affects lymphoblastic cells and is the most common neoplasm during childhood. Among the pharmaceuticals used in the treatment protocols for ALL, Asparaginase (ASNase) from Escherichia coli (EcAII) is an essential biodrug. Meanwhile, the use of EcAII in neoplastic trea...