5 documents found, page 1 of 1
The Use of New Therapies for Metastatic Castrate Resistant Prostate Cancer in t...
Botelho, Francisco; Miranda, André; Braga, Isaac; Leão, Ricardo; Teves, Frederico; Dias, Jorge; Rodrigues, Filipe; Oliveira, Jorge; Augusto, IsabelIntroduction:New drugs such as abiraterone (Abi), enzalutamide (Enz), cabazitaxel (Cab) and radium 223 (Rad) were recently approved for metastatic castrate resistant prostate cancer (mCRPC) patients. However, their use in clinical practice is largely unknown, so the objective of this research is to describe their use in mCRPC patients in public hospitals in the north of Portugal. Methods:All mCRPC patients trea...
Main Determinants of the Extent of Lymphadenectomy in Radical Cystectomy: A Stu...
Vale, Luís; Mendes, Filipa; Pacheco-Figueiredo, Luís; Antunes-Lopes, Tiago; Alturas-Silva, João; Martins-Silva, CarlosIntroduction: During radical cystectomy of patients with muscle-invasive bladder cancer, pelvic lymphadenectomy is used not only for an accurate staging, but also to provide local and regional control of the disease. Although recent studies evaluating the anatomical extent of lymphadenectomy recommend an extended template, the relation between the extent of lymphadenectomy and the number of dissected nodes rema...
Hormonal modulation in aging patients with erectile dysfunction and metabolic s...
Costa, Inês Campos; Carvalho, Hugo Nogueira; Pacheco-Figueiredo, Luís; Tomada, Inês; Tomada, NunoErectile dysfunction (ED), metabolic syndrome (MetS), and hypogonadism are closely related, often coexisting in the aging male. Obesity was shown to raise the risk of ED and hypogonadism, as well as other endocrinological disturbances with impact on erectile function. We selected 179 patients referred for ED to our andrology unit, aiming to evaluate gonadotropins and estradiol interplay in context of ED, MetS, ...
Health-related behaviours in the EpiPorto study: cancer survivors versus partic...
Pacheco-Figueiredo, Luís; Antunes, Luis; Bento, Maria José; Lunet, NunoCancer survivors are at an increased risk of a second primary cancer, partly due to unhealthy behaviours. In a cohort of adults (recruitment: 1999-2003; follow-up - linkage with population-based cancer registry: up to 2009) we compared the baseline exposure to smoking, alcohol and dietary intake and physical activity between: cancer survivors (CS) - cancer diagnosis before baseline (n=53); no cancer (NC) partic...
TP53 codon 72 polymorphism in susceptibility, overall survival, and adjuvant th...
Lima-Ramos, Vítor; Pacheco-Figueiredo, Luís; Costa, Sandra Maria Araújo da; Pardal, Fernando; Silva, Ana; Amorim, Júlia; Lopes, José Manuel; Reis, R. M.TP53 is a key tumor suppressor gene that encodes a transcriptional factor involved in several cellular mechanisms, including growth arrest, DNA repair, and induction of apoptosis. In addition to TP53 gene mutations, a common polymorphism, Arg72Pro, has been involved in the carcinogenesis process. The Pro72 variant has been associated with a slower induction of apoptosis and may influence the risk of cancer deve...