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Chitin-Glucan Complex Hydrogels
Araújo, Diana; Rodrigues, Thomas; Roma-Rodrigues, Catarina; Alves, Vítor D.; Fernandes, Alexandra R.; Freitas, FilomenaPublisher Copyright: © 2023 by the authors.; Chitin-glucan complex (CGC) hydrogels were fabricated by coagulation of the biopolymer from an aqueous alkaline solution, and their morphology, swelling behavior, mechanical, rheological, and biological properties were studied. In addition, their in vitro drug loading/release ability and permeation through mimic-skin artificial membranes (Strat-M) were assessed. The ...
Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPol
Araújo, Diana; Martins, Matilde; Concórdio-Reis, Patrícia; Roma-Rodrigues, Catarina; Morais, Maria; Alves, Vítor D.; Fernandes, Alexandra R.Publisher Copyright: © 2023 by the authors.; FucoPol, a fucose-rich polyanionic polysaccharide, was used for the first time for the preparation of hydrogel membranes (HMs) using Fe3+ as a crosslinking agent. This study evaluated the impact of Fe3+ and FucoPol concentrations on the HMs’ strength. The results show that, above 1.5 g/L, Fe3+ concentration had a limited influence on the HMs’ strength, and varying th...
Exploring the Drug-Loading and Release Ability of FucoPol Hydrogel Membranes
Araújo, Diana; Martins, Matilde; Freitas, FilomenaPublisher Copyright: © 2023 by the authors.; The polysaccharide FucoPol has recently been shown to yield hydrogel membranes (HMs) characterized by good mechanical properties, biocompatibility, and anti-inflammatory activity that render them promising biomaterials for use in the biomedical field. Subsequently to such findings, envisaging their development into novel delivery systems for topical applications, in ...
Deacetylation and Desuccinylation of the Fucose-Rich Polysaccharide Fucopol
Baptista, Sílvia; Araújo, Diana; Concórdio-Reis, Patrícia; Marques, Ana C.; Fortunato, Elvira; Alves, Vítor D.; Freitas, FilomenaLA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy—i4HB Publisher Copyright: © 2022 by the authors.; FucoPol is an acylated polysaccharide with demonstrated valuable functional properties that include a shear thinning fluid behaviour, a film-forming capacity, and an emulsion forming and stabilizing capacity. In this study, the different conditions (concentration, temperature, and tim...
Chitin-Glucan Complex Hydrogels: Optimization of Gel Formation and Demonstratio...
Araújo, Diana; Rodrigues, Thomas; Alves, Vítor D.; Freitas, FilomenaLA/P/0140/202019 SFRH/BD/140829/2018; Chitin-glucan complex (CGC) hydrogels were fabricated through a freeze–thaw procedure for biopolymer dissolution in NaOH 5 mol/L, followed by a dialysis step to promote gelation. Compared to a previously reported methodology that included four freeze–thaw cycles, reducing the number of cycles to one had no significant impact on the hydrogels’ formation, as well as reducing ...
Cation-mediated gelation of the fucose-rich polysaccharide FucoPol
Fialho, Letícia; Araújo, Diana; Alves, Vitor D.; Roma-Rodrigues, Catarina; Baptista, Pedro V.; Fernandes, Alexandra R.; Freitas, FilomenaFCT/MEC (UID/Multi/04378/2019). PEst-OE/AGR/UI0245/2014. POCI-01-0145-FEDER-007728 and POCI-01-0145-FEDER - 007265. SFRH/BD/140829/2018. SFRH/BPD/124612/2016.; This study describes for the first time the iron- and copper-mediated gelation of FucoPol, fucose-rich bacterial polysaccharide. The ability of FucoPol to gel in the presence of metal cations, including iron(III) and copper(II), was used for the preparat...
Biovalorization of lignocellulosic materials for xylitol production by the yeas...
Araújo, Diana; Costa, Tatiana; Freitas, FilomenaThe main goal of this study was to screen different lignocellulosic materials for their ability to support the cell growth of the yeast Komagataella pastoris and the production of xylitol. Several lignocellulosic materials, namely banana peels, brewer’s spent grains (BSGs), corncobs, grape pomace, grape stalks, and sawdust, were subjected to dilute acid hydrolysis to obtain sugar rich solutions that were tested...
Low temperature dissolution of yeast Chitin-Glucan complex and characterization...
Araújo, Diana; Alves, Vítor D.; Marques, Ana C.; Fortunato, Elvira; Reis, Maria A. M.; Freitas, FilomenaUIDB/04378/2020 UID/AGR/04129/2020 UID/CTM/50025/2019 BD/140829/2018 SFRH/BD/115173/2016; Chitin-glucan complex (CGC) is a copolymer composed of chitin and glucan moieties extracted from the cell-walls of several yeasts and fungi. Despite its proven valuable properties, that include antibacterial, antioxidant and anticancer activity, the utilization of CGC in many applications is hindered by its insolubility in...