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Loss of postprandial insulin clearance control by Insulin-degrading enzyme driv...
Borges, Diego O; Patarrão, Rita S; Ribeiro, Rogério T.; de Oliveira, Rita Machado; Duarte, Nádia; Belew, Getachew Debas; Martins, MadalenaSystemic insulin availability is determined by a balance between beta-cell secretion capacity and insulin clearance (IC). Insulin-degrading enzyme (IDE) is involved in the intracellular mechanisms underlying IC. The liver is a major player in IC control yet the role of hepatic IDE in glucose and lipid homeostasis remains unexplored. We hypothesized that IDE governs postprandial IC and hepatic IDE dysfunction am...
MPV17 mutations are associated with a quiescent energetic metabolic profile
Jacinto, Sandra; Guerreiro, Patrícia; de Oliveira, Rita Machado; Cunha-Oliveira, Teresa; Santos, Maria João; Grazina, Manuela; Rego, Ana CristinaMutations in the MPV17 gene are associated with hepatocerebral form of mitochondrial depletion syndrome. The mechanisms through which MPV17 mutations cause respiratory chain dysfunction and mtDNA depletion is still unclear. The MPV17 gene encodes an inner membrane mitochondrial protein that was recently described to function as a non-selective channel. Although its exact function is unknown, it is thought to be...
The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in...
de Oliveira, Rita Machado; Vicente Miranda, Hugo; Francelle, Laetitia; Pinho, Raquel; Szegö, Éva M.; Martinho, Renato; Munari, FrancescaSirtuin genes have been associated with aging and are known to affect multiple cellular pathways. Sirtuin 2 was previously shown to modulate proteotoxicity associated with age-associated neurodegenerative disorders such as Alzheimer and Parkinson disease (PD). However, the precise molecular mechanisms involved remain unclear. Here, we provide mechanistic insight into the interplay between sirtuin 2 and α-synucl...
National survey of the portuguese elderly nutritional status : study protocol
Madeira, Teresa; Plácido, Catarina Peixoto; Goulão, Beatriz; Mendonça, Nuno; Alarcão, Violeta; Santos, Nuno; de Oliveira, Rita Machado; Yngve, AgnetaBackground: Worldwide we are facing a serious demographic challenge due to the dramatic growth of the population over 60 years. It is expected that the proportion of this population will nearly double from 12 to 22 %, between 2015 and 2050. This demographic shift comes with major health and socio-economic concerns. Nutrition is a fundamental determinant of both health and disease and its role in extending a hea...