10 documents found, page 1 of 1

Synthesis and structure elucidation of dihydro-metabolites of the synthetic cat...

Background: Synthetic cathinones are new psychoactive substances widely abused due to their psychostimulant effects. Among them, pentedrone and methylone are part of the most consumed in the USA and Europe [1]. The metabolism of synthetic cathinones is well described in literature. Methylone can undergo, for instance, N-demethylation, O-demethylation, N-oxidation, and β-keto reduction to afford the metabolites ...

In vitro interactions between the ectomycorrhizal Pisolithus tinctorius and the...

Ectomycorrhizal fungi are crucial for forests sustainability. For Castanea sativa, ectomycorrhizal fungus Pisolithus tinctorius is an important mutualist partner. Saprotrophic fungi Hypholoma fasciculare, although used for biocontrol of Armillaria root disease, it negatively affected the interaction between the P. tinctorius and plant host roots, by compromise the formation of P. tinctorius-C. sativa mycorrhiza...

Volatile metabolomic signature of bladder cancer cell lines based on gas chroma...

Recent studies provide a convincing support that the presence of cancer cells in the body leads to the alteration of volatile organic compounds (VOCs) emanating from biological samples, particularly of those closely related with tumoral tissues. Thus, a great interest emerged for the study of cancer volatilome and subsequent attempts to confirm VOCs as potential diagnostic biomarkers.

Role of autophagy, apoptosis and oxidative stress in the toxicity of β-keto amp...

Effect of subtoxic and toxic concentrations of galactosamine in the metabolome ...

Chemical characterization and in vitro cyto- and genotoxicity of ‘legal high’ p...

Kratom is a popular ‘legal high’ mainly constituted by alkaloids extracted from the Mitragyna speciosa plant with mitragynine (MG) as the dominant active substance. The increasing use of Kratom for recreational purposes has alerted risk assessment bodies of the lack of information on the real composition and its potential health risks. The present study aimed to determine and compare the MG composition of 13 co...

Nuclear Magnetic Resonance metabolomics reveals an excretory metabolic signatur...

RCC usually develops and progresses asymptomatically and, when detected, it is frequently at advanced stages and metastatic, entailing a dismal prognosis. Therefore, there is an obvious demand for new strategies enabling an earlier diagnosis. The importance of metabolic rearrangements for carcinogenesis unlocked a new approach for cancer research, catalyzing the increased use of metabolomics. The present study ...

NMR metabolomics of renal cancer: an overview

This paper reviews the use of NMR metabolomics for the metabolic characterization of renal cancer. The existing challenges in the clinical management of this disease are first presented, followed by a brief introduction to the metabolomics approach, in the context of cancer research. A subsequent review of the literature on NMR metabolic studies of renal cancer reveals that the subject has been clearly underdev...

A gas chromatography-mass spectrometry multi-target method for the simultaneous...

In this work a fast and simple multi-target gas chromatography–mass spectrometry (GC–MS) method for the simultaneous detection and absolute quantification of amino acids, fatty acids and sterols in marine organisms is proposed. The methodology was applied to the characterization of the echinoderm Marthasterias glacialis Linnaeus spiny sea star extracts. The main factors influencing the extraction of target comp...

Postmortem analyses unveil the poor efficacy of decontamination, anti-inflammat...

Background: Fatalities resulting from paraquat (PQ) self-poisonings represent a major burden of this herbicide. Specific therapeutic approaches have been followed to interrupt its toxic pathway, namely decontamination measures to prevent PQ absorption and to increase its excretion from organism, as well as the administration of anti-inflammatory and immunosuppressive drugs. Until now, none of the postmortem stu...