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miRNA-21 regulates CD69 and IL-10 expression in canine leishmaniasis
Bragato, Jaqueline Poleto [UNESP]; Rebech, Gabriela Torres [UNESP]; de Freitas, Jéssica Henrique [UNESP]; dos Santos, Marilene Oliveira [UNESP]Made available in DSpace on 2022-04-28T19:52:39Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-03-01; Visceral leishmaniasis in humans is a chronic and fatal disease if left untreated. Canine leishmaniasis (CanL) is a severe public health problem because infected animals are powerful transmitters of the parasite to humans via phlebotomine vectors. Therefore, dogs are an essential target for control meas...
PD-1 function in apoptosis of T lymphocytes in canine visceral leishmaniasis
Chiku, Vanessa Marim [UNESP]; Silva, Kathlenn Liezbeth Oliveira [UNESP]; de Almeida, Breno Fernando Martins [UNESP]Made available in DSpace on 2018-12-11T17:02:06Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-08-01; Dogs infected with Leishmania infantum have a reduced number of T lymphocytes. PD-1 (Programmed cell death 1) a new member of the B7-CD28 family that is expressed by immune cells, and its binding to PD-L1 (CD274) or PD-L2 (CD273) induces the deactivation or apoptosis of T cells. This study aimed to eval...