2 documents found, page 1 of 1
Rab27a controls HIV-1 assembly by regulating plasma membrane levels of phosphat...
Gerber, P. P.; Cabrini, M.; Jancic, C.; Paoletti, L.; Banchio, C.; von Bilderling, C.; Sigaut, L.; Pietrasanta, L. I.; Duette, G.; Freed, E. O.During the late stages of the HIV-1 replication cycle, the viral polyprotein Pr55(Gag) is recruited to the plasma membrane (PM), where it binds phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and directs HIV-1 assembly. We show that Rab27a controls the trafficking of late endosomes carrying phosphatidylinositol 4-kinase type 2 α (PI4KIIα) toward the PM of CD4(+) T cells. Hence, Rab27a promotes high levels of ...
First use of thymus transplantation therapy for FOXN1 deficiency (nude/SCID) : ...
Markert, M. L.; Marques, J. G.; Neven, B.; Devlin, B. H.; McCarthy, E. A.; Chinn, I. K.; Albuquerque, A. S.; Silva, S. L.; Pignata, C.FOXN1 deficiency is a primary immunodeficiency characterized by athymia, alopecia totalis, and nail dystrophy. Two infants with FOXN1 deficiency were transplanted with cultured postnatal thymus tissue. Subject 1 presented with disseminated Bacillus Calmette-Guérin infection and oligoclonal T cells with no naive markers. Subject 2 had respiratory failure, human herpes virus 6 infection, cytopenias, and no circul...