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Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity...

Gomes, Ana Margarida; Soares, Maria Vieira; Ribeiro, Patrícia; Caldas, Joana; Póvoa, Vanda; Martins, Leila; Melão, Alice; Serra-Caetano, Ana

Adult B-cell acute lymphoblastic leukemia remains a major therapeutic challenge, requiring a better characterization of the molecular determinants underlying disease progression and resistance to treatment. Here, using a phospho-flow cytometry approach we show that adult diagnostic B-cell acute lymphoblastic leukemia specimens display PI3K/Akt pathway hyperactivation, irrespective of their BCR-ABL status and de...

Date: 2014   |   Origin: Repositório da Universidade de Lisboa
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