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Subclavian steal syndrome unmasked by large-vessel occlusion stroke: a case of ...

Moniz Dionísio, Joana; Blanco, Susana; Fragata, Isabel R.; Paiva Nunes, Ana; de Sousa, Diana Aguiar

A 52-year-old woman was admitted with acute onset of right hemispheric carotid syndrome. Computed tomography angiography revealed a right intracranial internal carotid artery occlusion and a thrombus at the aortic arch occluding the left subclavian artery. She had no palpable left radial pulse. No vertebral territory ischemia was documented. Angiography demonstrated a persistent primary trigeminal artery and a ...


Advances in cerebral venous thrombosis

de Sousa, Diana Aguiar; Lucas Neto, Lia

Cerebral venous thrombosis (CVT) is a less common form of stroke, predominantly affecting children and young adults. This review synthesizes recent advances in our understanding, diagnostic approaches, and management of patients with CVT, mostly drawing on data from international cohorts and clinical trials.


Coma in adult cerebral venous thrombosis: the BEAST study

Ranjan, Redoy; Ken‐Dror, Gie; Martinelli, Ida; Grandone, Elvira; Hiltunen, Sini; Lindgren, Erik; Margaglione, Maurizio; Duchez, Veronique Le Cam

Background and purpose: Coma is an independent predictor of poor clinical outcomes in cerebral venous thrombosis (CVT). We aimed to describe the association of age, sex, and radiological characteristics of adult coma patients with CVT. Methods: We used data from the international, multicentre prospective observational BEAST (Biorepository to Establish the Aetiology of Sinovenous Thrombosis) study. Only positive...


Basilar artery occlusion management: specialist perspectives from an internatio...

Edwards, Christopher; Drumm, Brian; Siegler, James E.; Schonewille, Wouter J.; Klein, Piers; Huo, Xiaochuan; Chen, Yimin; Abdalkader, Mohamad

Background and purpose: Two early basilar artery occlusion (BAO) randomized controlled trials did not establish the superiority of endovascular thrombectomy (EVT) over medical management. While many providers continue to recommend EVT for acute BAO, perceptions of equipoise in randomizing patients with BAO to EVT versus medical management may differ between clinician specialties. Methods: We conducted an intern...


Age‐related white matter hyperintensities and overactive bladder: a systematic ...

Pereira E Silva, Ricardo; de Sousa, Diana Aguiar; Lopes, Filipe Abadesso; Silva‐Ramos, Miguel; Verdelho, Ana

Introduction: Age-related white matter hyperintensities (ARWMHs) on brain magnetic resonance imaging have been associated with lower urinary tract symptoms/dysfunction (LUTS/LUTD), namely overactive bladder (OAB) and detrusor overactivity. We aimed to systematically review existing data on the association between ARWMH and LUTS and which clinical tools have been used for this assessment. Materials and methods: ...


Global impact of the COVID-19 pandemic on stroke volumes and cerebrovascular ev...

Nguyen, Thanh N.; Qureshi, Muhammad M.; Klein, Piers; Yamagami, Hiroshi; Mikulik, Robert; Czlonkowska, Anna; Abdalkader, Mohamad; Sedova, Petra

Background and objectives: Declines in stroke admission, IV thrombolysis (IVT), and mechanical thrombectomy volumes were reported during the first wave of the COVID-19 pandemic. There is a paucity of data on the longer-term effect of the pandemic on stroke volumes over the course of a year and through the second wave of the pandemic. We sought to measure the effect of the COVID-19 pandemic on the volumes of str...


Decompressive surgery in cerebral venous sinus thrombosis due to vaccine‐induce...

Krzywicka, Katarzyna; de Sousa, Diana Aguiar; Cordonnier, Charlotte; Bode, Felix J.; Field, Thalia S.; Michalski, Dominik; Pelz, Johann; Skjelland, Mona

Background and purpose: Cerebral venous sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia (CVST-VITT) is an adverse drug reaction occurring after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. CVST-VITT patients often present with large intracerebral haemorrhages and a high proportion undergoes decompressive surgery. Clinical characteristics, therapeutic manag...


Physical activity in vascular cognitive impairment: systematic review with meta...

Vítor, Joana; Melita, Catarina; Rodrigues, Mário; de Sousa, Diana Aguiar; Costa, João; Ferro, José; Verdelho, Ana

Background: Vascular cognitive impairment (VCI) is the second most common cause of cognitive impairment worldwide and includes a spectrum from vascular cognitive impairment no dementia (VCIND) to vascular dementia (VaD). There is no specific pharmacological treatment approved for VCI. Physical activity has been indicated to be a promising preventive measure for cognition, with direct as indirectly benefits, whi...


Endovascular treatment of cerebral sinus thrombosis due to vaccine-induced immu...

Weller, Johannes; Krzywicka, Katarzyna; van de Munckhof, Anita; Dorn, Franziska; Althaus, Katharina; Bode, Felix J.; Bandettini di Poggio, Monica

Introduction: There is little data on the role of endovascular treatment (EVT) of cerebral venous sinus thrombosis (CVST) due to vaccine-induced immune thrombotic thrombocytopenia (VITT). Here, we describe clinical characteristics and outcomes of CVST-VITT patients who were treated with EVT. Patients and methods: We report data from an international registry of patients who developed CVST within 28 days of SARS...


The role of optic nerve sheath ultrasonography in increased intracranial pressu...

Berhanu, David; Cardoso Ferreira, Joana; Pinto, Luis; de Sousa, Diana Aguiar; Lucas Neto, Lia; Tavares Ferreira, Joana

Objectives: To review the optimal diagnostic cut-off of ultrasonographic optic nerve sheath diameter (ONSD) in the diagnosis of increased intracranial pressure (IICP). Methods: A systematic search was conducted of available studies assessing the use of ONSD ultrasonography in patients with suspected IICP. Meta-analysis of diagnostic accuracy of ultrasonographic ONSD was performed using a bivariate model of rand...


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