6 documents found, page 1 of 1
Papel do exercício físico na regulação da proteína Notch1 em camundongos obesos...
Gaspar, Rafael Calais, 1992-Orientador: José Rodrigo Pauli; Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Aplicadas; Resumo: A proteína Notch1 apresenta uma importante função no metabolismo hepático, atuando no controle da produção de glicose e no metabolismo lipídico, impactando diretamente nos danos hepáticos causados pela obesidade, tornando-a um importante alvo de pesquisa. Por outro lado, o exercício fís...
Acute physical exercise increases leptin-induced hypothalamic extracellular sig...
Gaspar, Rafael Calais, 1992-; Muñoz, Vitor Rosetto, 1993-; Nakandakari, Susana Castelo Branco Ramos; Minuzzi, Luciele Guerra; Botezelli, José DiegoAgradecimentos: The authors thank Obesity and Comorbidities Research Center – OCRC and FAPESP (2016/18488-8) and CNPq (306535/2017-3) for all support during the experiment; The obesity is a result of energy imbalance and the increase in thermogenesis seems an interesting alternative for the treatment of this disease. The mechanism of energy expenditure through thermogenesis is tightly articulated in the hypotha...
Immune-endocrine responses and physical performance of master athletes during t...
Minuzzi, Luciele Guerra; Gaspar, Rafael Calais, 1992-; Muñoz, Vitor Rosetto, 1993-; Pauli, José Rodrigo, 1979-Agradecimentos: Firstly, the authors would like to thank all the master athletes that volunteered to participate in this study. The Research Center for Sport and Physical Activity (UID/DTP/04213/2016), Faculty of Sports Sciences and Physical Education, and the University of Coimbra funded the study. Also, the present manuscript was accomplished with support from CAPES, Coordination for the Improvement of Higher...
Efeito do exercício físico sobre a transdução do sinal da adiponectina no hipot...
Gaspar, Rafael Calais, 1992-Orientador: José Rodrigo Pauli; Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Aplicadas; Resumo: Introdução: A adiponectina apresenta uma importante ação na homeostase glicêmica, atuando na captação de glicose e na sensibilidade à insulina. Em nível central, recentemente, foi demonstrado que a adiponectina é capaz de modular a homeostase energética. Nesse sentido, uma das pri...
Hippocampal insulin signaling and neuroprotection mediated by physical exercise...
Botezelli, José Diego; Gaspar, Rafael Calais, 1992-; Pauli, José Rodrigo, 1979-Abstract: Epidemiological studies indicate continuous increases in the prevalence of Alzheimer’s Disease (AD) in the next few decades. The key feature of this disease is hippocampal neurodegeneration. This structure has an important role in learning and memory. Intense research efforts have sought to elucidate neuroprotective mechanisms responsible for hippocampal integrity. Insulin signaling seems to be a very...
Acute physical exercise increases glucose uptake in skeletal muscle of old rats...
Muñoz, Vitor Rosetto, 1993-; Moura, Leandro Pereira de, 1985-; Gaspar, Rafael Calais, 1992-; Silva, Vagner Ramon Rodrigues, 1985-Abstract: Senescence promotes several metabolic disorders, including insulin resistance (IR). It is known that physical exercise is an important non-pharmacological agent in the prevention and treatment of IR and consequently reducing the incidence of T2DM. Rho-kinase (Rock) has been postulated as an important protein that acts directly on the phosphorylation of IRS-1, collaborating up to 50% of glucose uptake ...