11 documents found, page 1 of 2
Triblock copolymers as versatile constituents of double stimuli-responsive ioni...
Rufino, Ana F. C. S.; Ribeiro, Sara C.; Coutinho, João A. P.; e Silva, Francisca A.; Freire, Mara G.This work proposes the use of triblock copolymers as structurally versatile constituents to develop double stimuli-responsive aqueous biphasic systems (ABS) comprising ionic liquids (ILs). Phase diagrams of ABS comprising cholinium acetate ([Ch][C2O2]) and triblock copolymers composed of polyethylene oxide (PEO) and polypropylene oxide (PPO) with adjustable compositions of PEO, 20% (PE 6200) and 40% (PE 6400), ...
Double-Stimuli-Responsive (Temperature and pH) Aqueous Biphasic Systems Compris...
Rufino, Ana F. C. S.; Bola, Joana M.; Capela, Emanuel V.; Coutinho, João A. P.; e Silva, Francisca A.; Freire, Mara G.Aqueous biphasic systems (ABS) can integrate multiple unit operations and operate under continuous mode, contributing to the development of sustainable separation processes. Encouraged by the designer solvent features of ionic liquids (ILs), we herein propose their use as components of double-stimuli-responsive (temperature- and pH-driven) ABS. Resorting to choline-alkanoate-based ILs as the pH-responsive compo...
Aqueous two-phase systems as multipurpose tools to improve biomarker analysis
Mendes, Maria S. M.; Rosa, Marguerita E.; Ramalho, Fábio; Freire, Mara G.; e Silva, Francisca A.Biomarker analysis in biological samples can boost risk profiling, diagnosis, prognosis and clinical decision-making, overall improving patient care. However, due to the complexity of most biological samples, biomarker analysis is a time-, cost-, labor- and resource-intensive task, commonly struggling with the lack of accurate results. To improve biomarker analysis, it is critical to develop efficient strategie...
Ionic liquid-based aqueous biphasic systems as one-step clean-up, microextracti...
González-Martín, Raúl; e Silva, Francisca A.; Trujillo-Rodríguez, María J.; Díaz Díaz, David; Lorenzo-Morales, Jacob; Freire, Mara G.; Pino, VerónicaAlthough saliva is a convenient human fluid for biomonitoring, current analytical set-ups for its analysis exhibit technical, sensitivity and instrumental compatibility constraints. To overcome these drawbacks, while following the Green Analytical Chemistry trends, this study is the first to propose the use of aqueous biphasic systems (ABSs) comprising the low cytotoxic butylguanidinium chloride ionic liquid (I...
Waste valorisation using ionic liquids
e Silva, Francisca A.; Sousa, Ana Catarina A.; Coutinho, João C.; Freire, Mara G,Modern societies produce large amounts of waste of many different types. This presents a problem in terms of management or disposal to prevent harm to human health and the environment. Additionally it represents a loss of potentially useful resources. In the circular economy concept nothing would ever become waste because everything would be re-usable or its components recoverable. Ionic liquids provide a poten...
Separation of mandelic acid enantiomers using solid-liquid biphasic systems wit...
Kholany, Mariam; e Silva, Francisca A.; Sintra, Tânia E.; Brandão, Paula; Ventura, Sónia P. M.; Coutinho, João A. P.This work aims to take full advantage of ionic liquids’ (ILs) “designer solvent” nature in order to expand the applicability of solid-liquid biphasic systems (SLBS) as alternative chiral resolution techniques. To this purpose, twelve chiral ILs, bearing chirality on the cation or the anion, were used as chiral selectors in SLBS to selectively precipitate mandelic acid enantiomers. The precipitation studies were...
Aquatic Toxicology of Ionic Liquids (ILs)
e Silva, Francisca A.; Coutinho, João A. P.; Ventura, Sónia P. M.Sem resumo disponível.
Aqueous biphasic systems using chiral ionic liquids for the enantioseparation o...
e Silva, Francisca A.; Kholany, Mariam; Sintra, Tânia E.; Caban, Magda; Stepnowski, Piotr; Ventura, Sónia P. M.; Coutinho, João A. P.This work aims at extending the applicability of chiral aqueous biphasic systems (ABS) to enantioseparations by using chiral ionic liquids (CILs) simultaneously as phase forming agents and chiral selectors. After determining the ternary phase diagrams of ABS composed of CILs and salts, these were used to ascertain the CIL structure and salt role on the ABS aptitude to separate mandelic acid enantiomers. Represe...
Recovery of nonsteroidal anti-inflammatory drugs from wastes using ionic-liquid...
e Silva, Francisca A.; Caban, Magda; Kholany, Mariam; Stepnowski, Piotr; Coutinho, João A. P.; Ventura, Sónia P. M.Aiming at outlining new strategies for the valorization of solid pharmaceutical wastes as viable alternatives to incineration, this work proposes the use of ionic liquids-based three phase partitioning (IL-based TPP) systems. Ibuprofen, naproxen, and ketoprofen, all belonging to the class of nonsteroidal anti-inflammatory drugs (NSAIDs), were adopted as model compounds. An integrated process has been conceptual...
Recovery of ibuprofen from pharmaceutical wastes using ionic liquids
e Silva, Francisca A.; Caban, Magda; Stepnowski, Piotr; Coutinho, Joao A. P.; Ventura, Sonia P. M.This work aims at developing a process to valorise pharmaceutical wastes through the recovery of pharmaceutically active compounds. The ibuprofen extraction and isolation from solid pharmaceutical wastes is used here as a case study and an integrated approach comprising the ibuprofen solid-liquid extraction, the removal of the insoluble excipients present in the pills, the target drug recovery and the recycling...