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miR-181a negatively regulates human γδ T cell differentiation into anti-tumor e...

Gordino, Gisela; Pereira, Sara; Gomes, Anita Q.; silva-Santos, Bruno; Ribot, Julie

Cytotoxicity and IFN-γ production by human γδ T cells underlie their potent anti-tumor functions. importantly, we have previously shown that ex vivo-isolated γδ thymocytes produced negligible IFN-γ and lacked cytolytic activity against leukemia cells but could acquire those properties upon stimulation with IL-2 or IL-15. This notwithstanding, the role of post-transcriptional mechanisms mediated by miRs in the a...

Date: 2019   |   Origin: Repositório Científico do Instituto Politécnico de Lisboa
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