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Improved Characteristics of RANKL Immuno-PET Imaging Using Radiolabeled Antibod...

Dewulf, Jonatan; Hrynchak, Ivanna; Geudens, Sarah; Pintelon, Isabel; Vangestel, Christel; Sereno, José; van Dam, Peter A; Abrunhosa, Antero

RANKL expression in the tumor microenvironment has been identified as a biomarker of immune suppression, negating the effect of some cancer immunotherapies. Previously we had developed a radiotracer based on the FDA-approved RANKL-specific antibody denosumab, [89Zr]Zr-DFO-denosumab, enabling successful immuno-PET imaging. Radiolabeled denosumab, however, showed long blood circulation and delayed tumor uptake, p...

Date: 2022   |   Origin: Estudo Geral - Universidade de Coimbra
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