3 documents found, page 1 of 1
Silk fibroin microparticles as carriers for delivery of human recombinant BMPs:...
Bessa, Paulo C.; Balmayor, Elizabeth Rosado; Azevedo, Helena S.; Nürnberger, Sylvia; Casal, Margarida; van Griensven, M.; Reis, R. L.; Redl, HeinzBone morphogenetic proteins (BMPs) are cytokines with strong ability to promote new bone formation. Herein, we report the use of silk fibroin microparticles as carriers for the delivery of BMP-2, BMP-9 or BMP-14. BMP-containing fibroin microparticles were prepared by a mild methodology using dropwise addition of ethanol, exhibiting mean diameters of 2.7 ± 0.3 μm. Encapsulation efficiencies varied between 67.9 ±...
Long term in vivo performance of starch-based scaffolds
Santos, T. C.; Marques, A. P.; Castro, António G.; van Griensven, M.; Redl, H.; Reis, R. L.[Excerpt] Natural-based biomaterials are mainly constituted by proteins or polysaccharides which, under certain circumstances, may be recognized as natural host invaders. Starch-based scaffolds, produced by different methodologies, have been shown to hold adequate properties regarding mechanical performance and in vitro biocompatibility. This study aimed at evaluating the in vivo inflammatory response to starch...
Chitosan/soy-based membranes enhance wound reepithelialization in partial thick...
Santos, T. C.; Marques, A. P.; Silva, S. S.; Oliveira, Joaquim M.; Mano, J. F.; Castro, A. G.; van Griensven, M.; Redl, H.; Reis, R. L.[Excerpt] Chitosan-based biomaterials proved to have promising characteristics for wound dressing and skin regeneration. In the context of developing new natural-based biomaterials for these applications, chitosan and soybean-based biomaterials were proposed. These materials were shown to be non cytotoxic and to impair human leukocytes activation in vitro. Thus the goal of this study was to evaluate the in vivo...